Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance
对主要蛋白酶 (Mpro) 中低频出现的治疗期间新出现的尼马替韦耐药突变进行功能和结构表征，揭示了 SARS-CoV-2 获得耐药性的独特进化途径
期刊:Journal of Infectious Diseases
影响因子:4.5
doi:10.1093/infdis/jiaf294
Deschenes, Natalie M; Pérez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A; Worrall, Liam J; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R; Lim, Jared; Young, Robert N; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C J; Jean, François; McGeer, Allison; Kozak, Robert A
