日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Multi-omic analysis of meningeal cerebral amyloid angiopathy reveals enrichment of unsubstituted glucosamine and extracellular proteins.

脑膜淀粉样血管病的多组学分析显示未取代的葡萄糖胺和细胞外蛋白富集

期刊:Journal of Neuropathology and Experimental Neurology
影响因子:3
doi:10.1093/jnen/nlaf018
Mayfield Joshua E, Rajic Alexander J, Aguilar-Calvo Patricia, Soldau Katrin, Flores Samantha, Lawrence Roger, Choudhury Biwsa, Ghassemian Majid, Pizzo Donald P, Wagner Steven L, Danque Garrett A, Sumowski Paige, Hansen Lawrence A, Goodwill Vanessa, Esko Jeffery D, Sigurdson Christina J
细胞生物学
发表日期：2025
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Human iPSC‐derived neuron modeling for the study of early‐onset Alzheimer’s disease

利用人类诱导多能干细胞衍生的神经元模型研究早发性阿尔茨海默病

期刊:
影响因子:
doi:10.1016/j.bbadis.2006.12.003
Greene, Lloyd A; Liu, David X; Troy, Carol M; Biswas, Subhas C; Valdes, Phoebe; Caldwell, Andrew B; Liu, Qing; Henry, Kenneth W; Fitzgerald, Michael Q; Muralidharan, Koushik; Ramachandran, Srinivasan; Karch, Celeste M; Yuan, Shauna H; Wagner, Steven L; Goldstein, Lawrence SB; Mobley, William C; Galasko, Douglas R; Subramaniam, Shankar
细胞生物学
阿尔茨海默症
神经科学
Human
干细胞
发育与干细胞
发表日期：2024
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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention

用于预防阿尔茨海默病的强效γ-分泌酶调节剂的临床前验证

期刊:Journal of Experimental Medicine
影响因子:10.6
doi:10.1084/jem.20202560
Rynearson, Kevin D; Ponnusamy, Moorthi; Prikhodko, Olga; Xie, Yuhuan; Zhang, Can; Nguyen, Phuong; Hug, Brenda; Sawa, Mariko; Becker, Ann; Spencer, Brian; Florio, Jazmin; Mante, Michael; Salehi, Bahar; Arias, Carlos; Galasko, Douglas; Head, Brian P; Johnson, Graham; Lin, Jiunn H; Duddy, Steven K; Rissman, Robert A; Mobley, William C; Thinakaran, Gopal; Tanzi, Rudolph E; Wagner, Steven L
阿尔茨海默症
发表日期：2021
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Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates

小鼠和非人灵长类动物中阿尔茨海默病相关γ-分泌酶的分子成像

期刊:Journal of Experimental Medicine
影响因子:10.6
doi:10.1084/jem.20182266
Xu, Yulong; Wang, Changning; Wey, Hsiao-Ying; Liang, Yingxia; Chen, Zude; Choi, Se Hoon; Ran, Chongzhao; Rynearson, Kevin D; Bernales, Daniela R; Koegel, Robert E; Fiedler, Stephanie A; Striar, Robin; Wagner, Steven L; Tanzi, Rudolph E; Zhang, Can
阿尔茨海默症
发表日期：2020
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γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion

γ-分泌酶直接插入脂质双层后，会重塑膜微区。

期刊:Langmuir
影响因子:3.9
doi:10.1021/acs.langmuir.0c01178
Barros, Marilia; Houlihan, William J; Paresi, Chelsea J; Brendel, Matthew; Rynearson, Kevin D; Lee, Chang-Wook; Prikhodko, Olga; Cregger, Cristina; Chang, Geoffrey; Wagner, Steven L; Gilchrist, M Lane; Li, Yue-Ming
发表日期：2020
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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.

新型甲氧基吡啶衍生的γ-分泌酶调节剂的设计与合成

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2020.115734
Rynearson Kevin D, Buckle Ronald N, Herr R Jason, Mayhew Nicholas J, Chen Xinchao, Paquette William D, Sakwa Samuel A, Yang Jinhai, Barnes Keith D, Nguyen Phuong, Mobley William C, Johnson Graham, Lin Juinn H, Tanzi Rudolph E, Wagner Steven L
免疫/内分泌
发表日期：2020
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Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

强效口服γ-分泌酶调节剂BPN-15606的药理学和毒理学特性

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1124/jpet.117.240861
Wagner, Steven L; Rynearson, Kevin D; Duddy, Steven K; Zhang, Can; Nguyen, Phuong D; Becker, Ann; Vo, Uyen; Masliah, Deborah; Monte, Louise; Klee, Justin B; Echmalian, Corinne M; Xia, Weiming; Quinti, Luisa; Johnson, Graham; Lin, Jiunn H; Kim, Doo Y; Mobley, William C; Rissman, Robert A; Tanzi, Rudolph E
发表日期：2017
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A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase

靶向尼卡斯特林的合成抗体片段影响γ-分泌酶的组装和运输

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M114.609636
Zhang, Xulun; Hoey, Robert; Koide, Akiko; Dolios, Georgia; Paduch, Marcin; Nguyen, Phuong; Wu, Xianzhong; Li, Yueming; Wagner, Steven L; Wang, Rong; Koide, Shohei; Sisodia, Sangram S
发表日期：2014
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Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

可溶性β-分泌酶调节剂选择性地抑制42个氨基酸的淀粉样β肽变体的产生，并增强多种羧基截短的淀粉样β物种的产生

期刊:Biochemistry
影响因子:3
doi:10.1021/bi401537v
Wagner Steven L, Zhang Can, Cheng Soan, Nguyen Phuong, Zhang Xulun, Rynearson Kevin D, Wang Rong, Li Yueming, Sisodia Sangram S, Mobley William C, Tanzi Rudolph E
其它
发表日期：2014
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Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion

通过储存操纵型钙离子通道的钙离子内流可减少阿尔茨海默病β-淀粉样蛋白肽的分泌

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M113.473355
Zeiger, William; Vetrivel, Kulandaivelu S; Buggia-Prévot, Virginie; Nguyen, Phuong D; Wagner, Steven L; Villereal, Mitchel L; Thinakaran, Gopal
阿尔茨海默症
发表日期：2013
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