日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool

Bnip3lb驱动的线粒体自噬维持胚胎造血干细胞库的命运

Meader, Eleanor; Walcheck, Morgan T; Leder, Mindy R; Delaney, Patrice; Falchetti, Marcelo; Jing, Ran; Li, Christopher; Kambli, Netra K; Wrighton, Paul J; Sugden, Wade W; Najia, Mohamad A; Oderberg, Isaac M; Taylor, Vivian M; LeBlanc, Zachary C; Quenzer, Eleanor D; Lim, Sung-Eun; Schlaeger, Thorsten; Daley, George Q; Goessling, Wolfram; North, Trista E

Dual-functioning Targeted ADAM17 Blocker CD16 (TAB16) mediates selective ADAM17 inhibition in NK cells and engages overexpressed ADAM17 in tumor cells to induce cytotoxicity.

双功能靶向ADAM17阻断剂CD16(TAB16)介导NK细胞中ADAM17的选择性抑制,并与肿瘤细胞中过表达的ADAM17结合以诱导细胞毒性。

Dixon Kate J, Hullsiek Robert, Wang Sam, Friess Ryan R, Matson Anders W, Soignier Yvette, Lenvik Alexander J, Wu Jianming, Hart Geoffrey T, Felices Martin, Walcheck Bruce

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells

ADAM17功能阻断抗体增强IL-15介导的NK细胞活化和增殖,该过程涉及CD16A、CD137和辅助细胞。

Anders W Matson ,Rob Hullsiek ,Kate J Dixon ,Sam Wang ,Anders J Lindstedt ,Ryan R Friess ,Shee Kwan Phung ,Tanya S Freedman ,Martin Felices ,Emily N Truckenbrod ,Jianming Wu ,Jeffrey S Miller ,Bruce Walcheck

iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma

iPSC 衍生的 NK 细胞表达高亲和力 IgG Fc 受体融合 CD64/16A,介导针对淋巴瘤的灵活、多肿瘤抗原靶向治疗

Kate J Dixon, Kristin M Snyder, Melissa Khaw, Robert Hullsiek, Zachary B Davis, Anders W Matson, Soheila Shirinbak, Bryan Hancock, Ryan Bjordahl, Martin Hosking, Jeffrey S Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck

iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting

表达 FcγR 融合 CD64/16A 的 iPSC 衍生自然杀伤细胞可配备抗体,实现多肿瘤抗原靶向

Kristin M Snyder, Kate J Dixon, Zachary Davis, Martin Hosking, Geoffrey Hart, Melissa Khaw, Anders Matson, Ryan Bjordahl, Bryan Hancock, Soheila Shirinbak, Jeffrey S Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck

Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production

利用 CRISPR/Cas9 技术敲除扩增的原代人 NK 细胞中的 SYK 激酶可增强细胞毒性和细胞因子产生。

James D Dahlvang ,Jenna K Dick ,Jules A Sangala ,Philippa R Kennedy ,Emily J Pomeroy ,Kristin M Snyder ,Juliette M Moushon ,Claire E Thefaine ,Jianming Wu ,Sara E Hamilton ,Martin Felices ,Jeffrey S Miller ,Bruce Walcheck ,Beau R Webber ,Branden S Moriarity ,Geoffrey T Hart

Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production

利用 CRISPR/Cas9 技术敲除扩增的原代人 NK 细胞中的 SYK 激酶可增强细胞毒性和细胞因子产生。

James D Dahlvang ,Jenna K Dick ,Jules A Sangala ,Philippa R Kennedy ,Emily J Pomeroy,Kristin M Snyder,Juliette M Moushon ,Claire E Thefaine ,Jianming Wu,Sara E Hamilton ,Martin Felices ,Jeffrey S Miller ,Bruce Walcheck ,Beau R Webber,Branden S Moriarity,Geoffrey T Hart

Chronic jetlag accelerates pancreatic neoplasia in conditional Kras-mutant mice

慢性时差反应会加速条件性 Kras 突变小鼠的胰腺肿瘤发生

Patrick B Schwartz ,Morgan T Walcheck ,Manabu Nukaya ,Derek M Pavelec ,Kristina A Matkowskyj ,Sean M Ronnekleiv-Kelly

Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-KrasG12D/+) mice

造血细胞中 Pdx1 的表达激活 Kras 突变,从而驱动 KC (Pdx1-Cre; LSL-KrasG12D/+) 小鼠发生白血病。

Morgan T Walcheck ,Manabu Nukaya ,Erik A Ranheim ,Kristina A Matkowskyj ,Sean Ronnekleiv-Kelly

Detection of Antibody-Dependent Cell-Mediated Cytotoxicity-Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization

NK-92-CD16A 细胞外化 CD107a 检测抗体依赖性细胞介导的细胞毒性支持抗体:抗体无岩藻糖基化的识别和检测优化

Judith Cruz Amaya, Bruce Walcheck, Julie Smith-Gagen, Vincent C Lombardi, Dorothy Hudig