日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual-functioning Targeted ADAM17 Blocker CD16 (TAB16) mediates selective ADAM17 inhibition in NK cells and engages overexpressed ADAM17 in tumor cells to induce cytotoxicity.

双功能靶向ADAM17阻断剂CD16(TAB16)介导NK细胞中ADAM17的选择性抑制,并与肿瘤细胞中过表达的ADAM17结合以诱导细胞毒性。

Dixon Kate J, Hullsiek Robert, Wang Sam, Friess Ryan R, Matson Anders W, Soignier Yvette, Lenvik Alexander J, Wu Jianming, Hart Geoffrey T, Felices Martin, Walcheck Bruce

An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model

在COVID-19小鼠模型中,ADAM17中和抗体可降低炎症和死亡率,同时增加病毒载量。

Hedges, Jodi F; Snyder, Deann T; Robison, Amanda; Grifka-Walk, Heather M; Blackwell, Karlin; Shepardson, Kelly; Kominsky, Douglas; Rynda-Apple, Agnieszka; Walcheck, Bruce; Jutila, Mark A

Engineering Anti-Tumor Monoclonal Antibodies and Fc Receptors to Enhance ADCC by Human NK Cells

通过工程改造抗肿瘤单克隆抗体和Fc受体来增强人NK细胞的ADCC作用

Dixon, Kate J; Wu, Jianming; Walcheck, Bruce

Ectodomain shedding by ADAM17 (a disintegrin and metalloproteinase 17) in canine neutrophils

犬中性粒细胞中ADAM17(一种解整合素和金属蛋白酶17)的胞外域脱落

Snyder, Kristin M; McAloney, Camille A; Montel, Joshua S; Modiano, Jaime F; Walcheck, Bruce

Pluripotent stem cell-derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

具有高亲和力不可裂解CD16a的多能干细胞衍生NK细胞介导更强的抗肿瘤活性

Zhu, Huang; Blum, Robert H; Bjordahl, Ryan; Gaidarova, Svetlana; Rogers, Paul; Lee, Tom Tong; Abujarour, Ramzey; Bonello, Gregory B; Wu, Jianming; Tsai, Pei-Fang; Miller, Jeffrey S; Walcheck, Bruce; Valamehr, Bahram; Kaufman, Dan S

Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis

利用单克隆抗体阻断ADAM17功能可提高小鼠多微生物脓毒症模型的存活率

Mishra, Hemant K; Ma, Jing; Mendez, Daniel; Hullsiek, Robert; Pore, Nabendu; Walcheck, Bruce

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy

ADAM17作为NK细胞中CD16A的调控检查点及其作为癌症免疫治疗潜在靶点的作用

Wu, Jianming; Mishra, Hemant K; Walcheck, Bruce

Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study.

在一项基于人群的病例对照研究中,MICA 多态性、s-MICA 水平与胰腺癌风险之间的关联

Onyeaghala Guillaume, Lane John, Pankratz Nathan, Nelson Heather H, Thyagarajan Bharat, Walcheck Bruce, Anderson Kristin E, Prizment Anna E

ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils.

ADAM17 可裂解人中性粒细胞中的 CD16b (FcγRIIIb)

Wang Yue, Wu Jianming, Newton Robert, Bahaie Nooshin S, Long Chunmei, Walcheck Bruce

Different signaling pathways stimulate a disintegrin and metalloprotease-17 (ADAM17) in neutrophils during apoptosis and activation

在细胞凋亡和活化过程中,不同的信号通路会刺激中性粒细胞中的解整合素和金属蛋白酶-17 (ADAM17) 的表达。

Wang, Yue; Robertson, John D; Walcheck, Bruce