日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1.

Parkin 的底物相互作用区指导线粒体 GTP 酶 Miro1 的泛素化

Koszela Joanna, Rintala-Dempsey Anne, Salzano Giulia, Pimenta Viveka, Kamarainen Outi, Gabrielsen Mads, Parui Aasna L, Shaw Gary S, Walden Helen

Stabilising proteins in solution using affordable and readily available small molecules

利用价格低廉且易于获得的小分子稳定溶液中的蛋白质

Tchiakam, Sandrine Bakam; Berger, Sarah L; Southall, June; Walden, Helen; Gabrielsen, Mads

Capturing the catalytic intermediates of parkin ubiquitination

捕获帕金蛋白泛素化的催化中间体

Connelly, Elizabeth M; Rintala-Dempsey, Anne C; Gundogdu, Mehmet; Freeman, E Aisha; Koszela, Joanna; Aguirre, Jacob D; Zhu, Grace; Kämäräinen, Outi; Tadayon, Roya; Walden, Helen; Shaw, Gary S

Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279

临床 USP1 抑制剂 KSQ-4279 作用机制的结构和生化见解

Rennie, Martin Luke; Gundogdu, Mehmet; Arkinson, Connor; Liness, Steven; Frame, Sheelagh; Walden, Helen

Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination

FANCI-FANCD2泛素化相互依赖的结构和生化基础

Lemonidis, Kimon; Rennie, Martin L; Arkinson, Connor; Chaugule, Viduth K; Clarke, Mairi; Streetley, James; Walden, Helen

The CCP4 suite: integrative software for macromolecular crystallography

CCP4套件:用于大分子晶体学的集成软件

Agirre, Jon; Atanasova, Mihaela; Bagdonas, Haroldas; Ballard, Charles B; Baslé, Arnaud; Beilsten-Edmands, James; Borges, Rafael J; Brown, David G; Burgos-Mármol, J Javier; Berrisford, John M; Bond, Paul S; Caballero, Iracema; Catapano, Lucrezia; Chojnowski, Grzegorz; Cook, Atlanta G; Cowtan, Kevin D; Croll, Tristan I; Debreczeni, Judit É; Devenish, Nicholas E; Dodson, Eleanor J; Drevon, Tarik R; Emsley, Paul; Evans, Gwyndaf; Evans, Phil R; Fando, Maria; Foadi, James; Fuentes-Montero, Luis; Garman, Elspeth F; Gerstel, Markus; Gildea, Richard J; Hatti, Kaushik; Hekkelman, Maarten L; Heuser, Philipp; Hoh, Soon Wen; Hough, Michael A; Jenkins, Huw T; Jiménez, Elisabet; Joosten, Robbie P; Keegan, Ronan M; Keep, Nicholas; Krissinel, Eugene B; Kolenko, Petr; Kovalevskiy, Oleg; Lamzin, Victor S; Lawson, David M; Lebedev, Andrey A; Leslie, Andrew G W; Lohkamp, Bernhard; Long, Fei; Malý, Martin; McCoy, Airlie J; McNicholas, Stuart J; Medina, Ana; Millán, Claudia; Murray, James W; Murshudov, Garib N; Nicholls, Robert A; Noble, Martin E M; Oeffner, Robert; Pannu, Navraj S; Parkhurst, James M; Pearce, Nicholas; Pereira, Joana; Perrakis, Anastassis; Powell, Harold R; Read, Randy J; Rigden, Daniel J; Rochira, William; Sammito, Massimo; Sánchez Rodríguez, Filomeno; Sheldrick, George M; Shelley, Kathryn L; Simkovic, Felix; Simpkin, Adam J; Skubak, Pavol; Sobolev, Egor; Steiner, Roberto A; Stevenson, Kyle; Tews, Ivo; Thomas, Jens M H; Thorn, Andrea; Valls, Josep Triviño; Uski, Ville; Usón, Isabel; Vagin, Alexei; Velankar, Sameer; Vollmar, Melanie; Walden, Helen; Waterman, David; Wilson, Keith S; Winn, Martyn D; Winter, Graeme; Wojdyr, Marcin; Yamashita, Keitaro

Structural basis of generic versus specific E2-RING E3 interactions in protein ubiquitination

蛋白质泛素化中通用型与特异性 E2-RING E3 相互作用的结构基础

Gundogdu, Mehmet; Walden, Helen

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

UbcH7~Ub 和磷酸化 Ubl 结构域的协同募集触发帕金蛋白的激活

Condos, Tara Ec; Dunkerley, Karen M; Freeman, E Aisha; Barber, Kathryn R; Aguirre, Jacob D; Chaugule, Viduth K; Xiao, Yiming; Konermann, Lars; Walden, Helen; Shaw, Gary S

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Parkin-磷酸泛素复合物揭示了RBR连接酶活性所需的隐蔽泛素结合位点

Kumar, Atul; Chaugule, Viduth K; Condos, Tara E C; Barber, Kathryn R; Johnson, Clare; Toth, Rachel; Sundaramoorthy, Ramasubramanian; Knebel, Axel; Shaw, Gary S; Walden, Helen

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening

通过片段筛选对范可尼贫血泛素结合酶Ube2T进行变构靶向

Morreale, Francesca E; Bortoluzzi, Alessio; Chaugule, Viduth K; Arkinson, Connor; Walden, Helen; Ciulli, Alessio