日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The succinate prodrug NV354 prevents brain lesions and late-stage motor dysfunction in mitochondrial complex I deficiency.

琥珀酸前药 NV354 可预防线粒体复合物 I 缺乏症引起的脑损伤和晚期运动功能障碍。

McManus Meagan J, Zhu Yi, Alves Cesar, Kohli Neha, Prada-Dacasa Patricia, Sanchez-Benito Laura, Sanz Elisenda, Yee Irene, Robinson Lozen, Sheldon Malkah, McHugh Walter J, Ranganathan Abhay, Meng Jennie, Duncan Nina, Grönberg Alvar, Wallace Douglas C, Piel Sarah, Karlsson Michael, Moss Steven J, Webster Lee, Hansson Magnus J, Elmér Eskil, Ehinger Johannes K, Quintana Albert, Kilbaugh Todd J

Respiratory viral infections awaken metastatic breast cancer cells in lungs.

呼吸道病毒感染会激活肺部转移性乳腺癌细胞

Chia Shi B, Johnson Bryan J, Hu Junxiao, Valença-Pereira Felipe, Chadeau-Hyam Marc, Guntoro Fernando, Montgomery Hugh, Boorgula Meher P, Sreekanth Varsha, Goodspeed Andrew, Davenport Bennett, De Dominici Marco, Zaberezhnyy Vadym, Schleicher Wolfgang E, Gao Dexiang, Cadar Andreia N, Petriz-Otaño Lucia, Papanicolaou Michael, Beheshti Afshin, Baylin Stephen B, Guarnieri Joseph W, Wallace Douglas C, Costello James C, Bartley Jenna M, Morrison Thomas E, Vermeulen Roel, Aguirre-Ghiso Julio A, Rincon Mercedes, DeGregori James

Hepatocyte mitochondrial NAD(+) content is limiting for liver regeneration.

肝细胞线粒体 NAD(+) 含量限制了肝脏再生。

Mukherjee Sarmistha, Velázquez Aponte Ricardo A, Perry Caroline E, Lee Won Dong, Janssen Kevin A, Niere Marc, Adzika Gabriel K, Lu Mu-Jie, Chan Hsin-Ru, Zou Xiangyu, Chen Beishan, Bye Nicole, Xiao Teresa, Yook Jin-Seon, Salik Oniel, Frederick David W, Gaspar Ryan B, Doan Khanh V, Davis James G, Rabinowitz Joshua D, Wallace Douglas C, Snyder Nathaniel W, Kajimura Shingo, Cambronne Xiaolu A, Ziegler Mathias, Baur Joseph A

ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer.

ZNFX1 在癌症中作为表观遗传诱导的病原体模拟和炎症小体信号传导的主调节因子发挥作用

Stojanovic Lora, Abbotts Rachel, Tripathi Kaushelendra, Coon Collin M, Rajendran Saranya, Abbasi Farid Elnaz, Hostetter Galen, Guarnieri Joseph W, Wallace Douglas C, Liu Sheng, Wan Jun, Calendo Gennaro, Marker Rebecca, Gohari Zahra, Inayatullah Mohammed M A, Tiwari Vijay K, Kader Tanjina, Santagata Sandro, Drapkin Ronny, Kommoss Stefan, Pfisterer Jacobus, Konecny Gottfried E, Coopergard Ryan, Issa Jean-Pierre J, Winterhoff Boris J N, Topper Michael J, Sandusky George E, Miller Kathy D, Baylin Stephen B, Nephew Kenneth P, Rassool Feyruz V

Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1(-/-) plus mtDNA mutant mice

AAV-Ant1 对线粒体功能障碍的部分修复可保护 Ant1(-/-) 合并 mtDNA 突变小鼠免受扩张型心肌病的侵害

Angelin, Alessia; Keller, Kierstin; Lu, Peiran; Guarnieri, Joseph W; Widjaja, Gabrielle A; Sule, Rasheed; Janssen, Kevin; Olali, Arnold; Cen, Zimu; Carosi, Valeria; Beauplan, Maina; Murdock, Deborah G; Potluri, Prasanth; Pei, Liming; Wallace, Douglas C

Respiration defects limit serine synthesis required for lung cancer growth and survival.

呼吸缺陷会限制肺癌生长和存活所需的丝氨酸合成

Cararo Lopes Eduardo, Shi Fuqian, Sawant Akshada, Ibrahim Maria, Gomez-Jenkins Maria, Hu Zhixian, Manchiraju Pranav, Bhatt Vrushank, Wang Wenping, Hinrichs Christian S, Wallace Douglas C, Su Xiaoyang, Rabinowitz Joshua D, Chan Chang S, Guo Jessie Yanxiang, Ganesan Shridar, Lattime Edmund C, White Eileen

Combined ketone body and glutamine supplementation restores aerobic energy production in AGC1-deficient neuronal progenitors.

酮体和谷氨酰胺联合补充可恢复 AGC1 缺乏的神经元祖细胞的有氧能量产生。

Barile Simona Nicole, Magnifico Maria Chiara, Poeta Eleonora, Distelmaier Felix, Viggiano Luigi, Balboni Nicola, Protti Michele, Petralla Sabrina, Pignataro Antonella, Volpe Giacomo, De Luise Monica, Bonora Massimo, Antonicelli Marica, Babini Giorgia, Massenzio Francesca, Porcelli Vito, Lama Eleonora, Arrigoni Roberto, Pisano Isabella, Addabbo Veronica, Campana Anna, Begnozzi Francesca, Anderson Stewart A, Fiermonte Giuseppe, Giorgi Federico Manuel, Pinton Paolo, Palmieri Ferdinando, Gasparre Giuseppe, Mercolini Laura, Palmieri Luigi, Wallace Douglas C, Hentschel Julia, Monti Barbara, Lasorsa Francesco Massimo

Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling

线粒体DNA谱系通过T细胞活性氧信号传导决定肿瘤进展

Yardeni, Tal; Olali, Arnold Z; Chen, Hsiao-Wen; Wang, Liqing; Haltom, Jeffrey A; Zenab, Angi; Morrow, Ryan; Butic, Arrienne; Murdock, Deborah G; Waymire, Katrina G; MacGregor, Grant R; Boursi, Ben; Beier, Ulf H; Hancock, Wayne W; Wallace, Douglas C

A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron-sulfur cluster and supercomplex formation

MEPAN小鼠模型表明线粒体脂肪酸合成在铁硫簇和超复合物形成中发挥作用

Murdock, Deborah G; Janssen, Kevin A; Keller, Kierstin; Mitchell, Katherine L; Beauplan, Maina; O'Brien, William T; D'Alessandro, Lia; Haltom, Jeffrey A; Wallace, Douglas C

Vitamin A treatment restores vision failures arising from Leber's hereditary optic neuropathy-linked mtDNA mutation.

维生素 A 治疗可以恢复由莱伯氏遗传性视神经病变相关的 mtDNA 突变引起的视力障碍

Ai Cheng, Li Huiying, Wang Chunyan, Ji Yanchun, Wallace Douglas C, Qian Junbin, Zhu Yimin, Guan Min-Xin