日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Parkinson's-Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa.

帕金森病相关的 LRRK2 和 GBA1 突变调节外周对铜绿假单胞菌的免疫反应。

Mark Julian R, Staley Hannah A, Titus Ann M, Agin-Liebes Julian, Garrido Alicia, Hughes Laura, Dzamko Nicolas, Wallings Rebecca L, Tansey Malú Gámez

Tissue-specific immune and MAPK signatures in models of reduced Progranulin and Western diet.

减少的粒原蛋白和西方饮食模型中的组织特异性免疫和 MAPK 特征。

Merchak Andrea R, de Sousa Rodrigues Maria Elizabeth, Cole Cassandra, Neighbarger Noelle, Bhavsar Nilay, Wallings Rebecca L, Joers Valerie, Chang Jianjun, Kelly Sean D, Sampson Timothy R, Tansey Malú Gámez

ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses.

在突变型 GRN 和 Grn 缺陷型外周髓系细胞中,ASO 介导的 GPNMB 敲低会破坏溶酶体功能和免疫反应

Wallings Rebecca L, Gillett Drew A, Staley Hannah A, Mahn Savanna, Mark Julian, Neighbarger Noelle, Kordasiewicz Holly, Hirst Warren D, Tansey Malú Gámez

Interferon gamma stimulates coordinated changes in LRRK2, GCase, and cathepsin activities in idiopathic and genetic Parkinson's disease monocytes

干扰素γ刺激特发性和遗传性帕金森病单核细胞中LRRK2、GCase和组织蛋白酶活性发生协调变化

Hughes, Laura P; Wallings, Rebecca L; Agin-Liebes, Julian; Alcalay, Roy N; Garrido, Alicia; Tansey, Malú Gámez; Dzamko, Nicolas

Peripheral immune cell response to stimulation stratifies Parkinson's disease progression from prodromal to clinical stages.

外周免疫细胞对刺激的反应可将帕金森病的进展从前驱期到临床期进行分层

Mark Julian R, Titus Ann M, Staley Hannah A, Alvarez Stephan, Mahn Savanna, McFarland Nikolaus R, Wallings Rebecca L, Tansey Malú Gámez

MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation

MHCII 减少不足以保护小鼠免受 α-突触核蛋白诱导的退行性变,帕金森病 HLA 位点表现出表观遗传调控。

Elizabeth M Kline ,Janna E Jernigan ,Christopher D Scharer ,Jeffrey Maurer ,Sakeenah L Hicks ,Mary K Herrick ,Rebecca L Wallings ,Sean D Kelly ,Jianjun Chang ,Kelly B Menees ,Nikolaus R McFarland ,Jeremy M Boss ,Malú Gámez Tansey ,Valerie Joers

MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation.

MHCII 减少不足以保护小鼠免受 α-突触核蛋白诱导的退化,帕金森病 HLA 位点表现出表观遗传调控

Kline Elizabeth M, Jernigan Janna E, Scharer Christopher D, Maurer Jeffrey, Hicks Sl Sakeenah, Herrick M Mary K, Wallings Rebecca L, Kelly Sean D, Chang Jianjun, Menees Kelly B, McFarland Nikolaus R, Boss Jeremy M, Tansey Malú Gámez, Joers Valerie

The R1441C-Lrrk2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner in mice

R1441C-Lrrk2突变以年龄和性别依赖的方式诱导小鼠髓系免疫细胞耗竭。

Wallings, Rebecca L; McFarland, Karen; Staley, Hannah A; Neighbarger, Noelle; Schaake, Susen; Brüggemann, Norbert; Zittel, Simone; Usnich, Tatiana; Klein, Christine; Sammler, Esther M; Tansey, Malú Gámez

Alzheimer's disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner

阿尔茨海默病相关的保护性变异体Plcg2-P522R以性别二态性方式调节外周巨噬细胞功能。

Hannah A Staley ,Janna E Jernigan ,MacKenzie L Bolen ,Ann M Titus ,Noelle Neighbarger ,Cassandra Cole ,Kelly B Menees ,Rebecca L Wallings ,Malú Gámez Tansey

Investigating the role and regulation of GPNMB in progranulin-deficient macrophages

研究 GPNMB 在前颗粒蛋白缺乏的巨噬细胞中的作用和调节

Drew A Gillett, Noelle K Neighbarger, Cassandra Cole, Rebecca L Wallings #, Malú Gámez Tansey #