日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The factor XIa antibody osocimab strongly inhibits clotting in extracorporeal circuits with human blood and in baboons

因子XIa抗体osocimab能强烈抑制体外循环回路中人血和狒狒体内的凝血。

期刊:Research and Practice in Thrombosis and Haemostasis
影响因子:3.4
doi:10.1016/j.rpth.2025.102932
Samaha, Eslam; Schwameis, Michael; Schranz, Sabine; Kovacevic, Katarina D; Watschinger, Bruno; Stoiber, Martin; Wolf, Christopher; Wallisch, Michael; Gruber, András; Tucker, Erik I; Buchmüller, Anja; Jilma, Bernd
发表日期：2025
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Pharmacologic targeting of coagulation factors XII and XI by monoclonal antibodies reduces thrombosis in nitinol stents under flow

利用单克隆抗体靶向凝血因子XII和XI进行药理学治疗，可降低流动条件下镍钛合金支架内的血栓形成。

期刊:Journal of Thrombosis and Haemostasis
影响因子:5
doi:10.1016/j.jtha.2024.01.023
Keeling, Novella M; Wallisch, Michael; Johnson, Jennifer; Le, Hillary H; Vu, Helen H; Jordan, Kelley R; Puy, Cristina; Tucker, Erik I; Nguyen, Khanh P; McCarty, Owen J T; Aslan, Joseph E; Hinds, Monica T; Anderson, Deirdre E J
单克隆抗体
心血管
发表日期：2024
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Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia

在非人灵长类动物高脂血症模型中，凝血因子FXI的激活会促进内皮炎症并增强血小板活化。

期刊:Research and Practice in Thrombosis and Haemostasis
影响因子:3.4
doi:10.1016/j.rpth.2023.102276
Kohs, Tia C L; Vu, Helen H; Jordan, Kelley R; Parra-Izquierdo, Iván; Hinds, Monica T; Shatzel, Joseph J; Kievit, Paul; Morgan, Terry K; Yunga, Samuel Tassi; Ngo, Thuy T M; Aslan, Joseph E; Wallisch, Michael; Lorentz, Christina U; Tucker, Erik I; Gailani, David; Lindner, Jonathan R; Puy, Cristina; McCarty, Owen J T
炎症/感染
炎症
血小板
发表日期：2024
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Safety and tolerability of the protein C activator AB002 in end-stage renal disease patients on hemodialysis: a randomized phase 2 trial

蛋白C激活剂AB002在接受血液透析的终末期肾病患者中的安全性和耐受性：一项随机II期试验

期刊:
影响因子:
doi:10.1038/s43856-024-00575-y
Verbout, Norah G; Lorentz, Christina U; Markway, Brandon D; Wallisch, Michael; Marbury, Thomas C; Di Cera, Enrico; Shatzel, Joseph J; Gruber, András; Tucker, Erik I
发表日期：2024
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Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

因子XII在镰状细胞病中导致血栓并发症和血管阻塞。

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2022017074
Sparkenbaugh, Erica M; Henderson, Michael W; Miller-Awe, Megan; Abrams, Christina; Ilich, Anton; Trebak, Fatima; Ramadas, Nirupama; Vital, Shantel; Bohinc, Dillon; Bane, Kara L; Chen, Chunsheng; Patel, Margi; Wallisch, Michael; Renné, Thomas; Gruber, Andras; Cooley, Brian; Gailani, David; Kasztan, Malgorzata; Vercellotti, Gregory M; Belcher, John D; Gavins, Felicity E; Stavrou, Evi X; Key, Nigel S; Pawlinski, Rafal
细胞生物学
心血管
发表日期：2023
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Titanium is a potent inducer of contact activation: implications for intravascular devices

钛是接触激活的强效诱导剂：对血管内装置的意义

期刊:Journal of Thrombosis and Haemostasis
影响因子:5
doi:10.1016/j.jtha.2022.12.014
Litvak, Maxim; Shamanaev, Aleksandr; Zalawadiya, Sandip; Matafonov, Anton; Kobrin, Anton; Feener, Edward P; Wallisch, Michael; Tucker, Erik I; McCarty, Owen J T; Gailani, David
发表日期：2023
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Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

因子 XII 在感染金黄色葡萄球菌的狒狒的器官衰竭和死亡中起致病作用

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2020009345
Silasi, Robert; Keshari, Ravi S; Regmi, Girija; Lupu, Cristina; Georgescu, Constantin; Simmons, Joe H; Wallisch, Michael; Kohs, Tia C L; Shatzel, Joseph J; Olson, Sven R; Lorentz, Christina U; Puy, Cristina; Tucker, Erik I; Gailani, David; Strickland, Sidney; Gruber, András; McCarty, Owen J T; Lupu, Florea
炎症/感染
发表日期：2021
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The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

无肝素血液透析中接触激活抑制剂AB023的应用：一项随机II期临床试验的结果

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2021011725
Lorentz, Christina U; Tucker, Erik I; Verbout, Norah G; Shatzel, Joseph J; Olson, Sven R; Markway, Brandon D; Wallisch, Michael; Ralle, Martina; Hinds, Monica T; McCarty, Owen J T; Gailani, David; Weitz, Jeffrey I; Gruber, András
发表日期：2021
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Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate

评估降低非人灵长类动物凝血因子VII水平的抗止血和抗血栓作用

期刊:Cellular and Molecular Bioengineering
影响因子:5
doi:10.1007/s12195-020-00613-4
Wallisch, Michael; Olson, Sven R; Crosby, Jeffrey; Johnson, Jennifer; Murray, Susan F; Shatzel, Joseph J; Tucker, Erik I; McCarty, Owen J T; Hinds, Monica T; Monia, Brett P; Gruber, András
心血管
Primate
发表日期：2020
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Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates.

在非人灵长类动物体外膜肺氧合器灌注模型中，抗体抑制接触因子 XII 可减少血小板沉积

期刊:Research and Practice in Thrombosis and Haemostasis
影响因子:3.4
doi:10.1002/rth2.12309
Wallisch Michael, Lorentz Christina U, Lakshmanan Hari H S, Johnson Jennifer, Carris Marschelle R, Puy Cristina, Gailani David, Hinds Monica T, McCarty Owen J T, Gruber András, Tucker Erik I
其它
Human
发表日期：2020
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