Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5.
由于 MK2 与 MK3 和 MK5 存在协同作用,因此靶向降解 MK2 不足以阻止人类细胞中炎症细胞因子的产生。
期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1712589
Yang Bin, Fang Guoqiang, Marx Isaac, Liu Guang, Skouras Stephanie, Sharma Kirti, Walther Dirk M, Bollinger Martinez Sarah, Hubeau Cedric, Shi Yatao, De Savi Chris, Huang Xin, Huhn Annissa, Sawant Rupa, Proctor William R, Dixit Vaishali S, Dong Huijun, Weiss Matthew M, Mainolfi Nello, Slavin Anthony, Long Andrew J, Williams Juliet A, Byrne Fergus R