日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cryo-EM structures of human P2X2/3 heteromer channel reveal the structural basis of ligand selectivity

人P2X2/3异聚体通道的冷冻电镜结构揭示了配体选择性的结构基础

Cheng, Xinyu; Zhang, Wei; Che, Tong; Guo, Hongmin; Nan, Weiwei; Zhang, Yuting; Fu, Ying; Wan, Shuangyan; Zhang, Jin

Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity

结构导向设计具有抗抑郁活性的皮摩尔级大环TRPC5通道抑制剂

Che, Tong; Chen, Yixiang; Cheng, Xinyu; Hu, Han; Wu, Xiaoyun; Zhang, Yuting; Yang, Xiaoqiang; Liu, Yinzhen; Liu, Hui; Nan, Weiwei; Wan, Shuangyan; Yang, Mingxing; Zeng, Bo; Li, Jian; Zhang, Jin; Xiong, Bing

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

二级结构转变和双重 PIP2 结合决定了心脏 KCNQ1-KCNE1 通道的门控机制

Zhong, Ling; Lin, Xiaoqing; Cheng, Xinyu; Wan, Shuangyan; Hua, Yaoguang; Nan, Weiwei; Hu, Bin; Peng, Xiangjun; Zhou, Zihan; Zhang, Qiansen; Yang, Huaiyu; Noé, Frank; Yan, Zhenzhen; Jiang, Dexiang; Zhang, Hangyu; Liu, Fengjiao; Xiao, Chenxin; Zhou, Zhuo; Mou, Yimin; Yu, Haijie; Ma, Lijuan; Huang, Chen; Wong, Vincent Kam Wai; Chung, Sookja Kim; Shen, Bing; Jiang, Zhi-Hong; Neher, Erwin; Zhu, Wandi; Zhang, Jin; Hou, Panpan

The deubiquitylase OTUB1 drives gemcitabine resistance in pancreatic cancer by enhancing pyrimidine metabolism through modulating DHODH mRNA stability.

去泛素化酶 OTUB1 通过调节 DHODH mRNA 的稳定性来增强嘧啶代谢,从而驱动胰腺癌对吉西他滨产生耐药性

Zhang Wenming, Liu Rui, Hu Junwen, Wan Shuangyan, Zou Yeqin, Che Tong, Zhang Jin, Chen Leifeng, Peng Xiaogang

Structural mechanism of human HCN1 hyperpolarization-activated channel inhibition by ivabradine.

伊伐布雷定抑制人HCN1超极化激活通道的结构机制

Che Tong, Zhang Wei, Cheng Xinyu, Lv Sijia, Zhang Minqing, Zhang Yuting, Yang Tingting, Nan Weiwei, Wan Shuangyan, Zeng Bo, Li Jian, Xiong Bing, Zhang Jin