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The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase

人类运输和高尔基体组织2同源物（TANGO2）的晶体结构提示存在一种半胱氨酸N端亲核试剂（Ntn）水解酶。

期刊:Acta Crystallographica Section D-Structural Biology

影响因子:3.8

doi:10.1107/S2059798326001968

Zhou, Dayong; Chen, Lirong; Rose, John; Wang, Bi Cheng

发表日期：2026

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Bevacizumab combined with chemotherapy and anti-PD-1 therapy for the first-line treatment of previously untreated metastatic triple-negative breast cancer

贝伐珠单抗联合化疗和抗PD-1疗法用于一线治疗既往未接受治疗的转移性三阴性乳腺癌

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-012312

Letter to the editor: effects of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer-a prospective observation study

致编辑的信：放射治疗对难治性微卫星稳定型转移性结直肠癌患者接受呋喹替尼联合信迪利单抗治疗的影响——一项前瞻性观察研究

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-011678

Letter to the editor: safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcinoma beyond up-to-seven criteria

致编辑的信：PD-1抑制剂（信迪利单抗）联合经动脉化疗栓塞术作为中晚期肝细胞癌患者初始治疗方案（超出七项标准）的安全性和有效性

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-011909

Correspondence on 'Pembrolizumab hybrid dosing is non-inferior to flat dosing in advanced non-small cell lung cancer: a real-world, retrospective bicenter cohort study' by Smeenk et al

关于 Smeenk 等人发表的题为“在晚期非小细胞肺癌中，帕博利珠单抗混合给药方案不劣于固定剂量方案：一项真实世界回顾性双中心队列研究”的来信

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-011895

Storage of the vital metal tungsten in a dominant SCFA-producing human gut microbe Eubacterium limosum and implications for other gut microbes

人体肠道优势短链脂肪酸产生菌——黏液真杆菌中重要金属钨的储存及其对其他肠道微生物的影响

期刊:mBio

影响因子:4.7

doi:10.1128/mbio.02605-24

Shao, Nana; Zhou, Dayong; Schut, Gerrit J; Poole, Farris L; Coffey, Sydney B; Donaghy, Aaron P; Putumbaka, Saisuki; Thorgersen, Michael P; Chen, Lirong; Rose, John; Wang, Bi-Cheng; Adams, Michael W W

I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation

晶体衍射数据质量评估中 I/σI 与 {Rmerg, Rmeas, Rpim, CC1/2} 的关系

期刊:

影响因子:

doi:10.1101/2024.12.10.627855

Fu, Zheng-Qing; Geisbrecht, Brian V; Bouyain, Samuel; Dyda, Fred; Chrzas, John; Kandavelu, Palani; Miller, Darcie J; Wang, Bi-Cheng

发表日期：2025

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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway

miR-26a 通过抑制 LIMS1/ILK 通路对血管紧张素 II 诱发的慢性肾脏病小鼠模型中的心肾损伤的治疗作用

期刊:Chinese Medical Journal

影响因子:

doi:10.1097/CM9.0000000000002978

Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu

Macrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155

巨噬细胞衍生的外泌体通过递送 miR-155 促进管状上皮细胞端粒脆性和衰老

期刊:Cell Communication and Signaling

影响因子:8.2

doi:10.1186/s12964-024-01708-5

Qing Yin #, Tao-Tao Tang #, Xiao-Yu Lu, Wei-Jie Ni, Di Yin, Yi-Lin Zhang, Wei Jiang, Yue Zhang, Zuo-Lin Li, Yi Wen, Wei-Hua Gan, Ai-Qing Zhang, Lin-Li Lv, Bin Wang, Bi-Cheng Liu

Cadonilimab (mono anti-PD-1/CTLA-4 therapy) in advanced esophageal squamous cell carcinoma

卡多尼利单抗（单药抗PD-1/CTLA-4疗法）治疗晚期食管鳞状细胞癌

The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase

人类运输和高尔基体组织2同源物（TANGO2）的晶体结构提示存在一种半胱氨酸N端亲核试剂（Ntn）水解酶。

Bevacizumab combined with chemotherapy and anti-PD-1 therapy for the first-line treatment of previously untreated metastatic triple-negative breast cancer

贝伐珠单抗联合化疗和抗PD-1疗法用于一线治疗既往未接受治疗的转移性三阴性乳腺癌

Letter to the editor: effects of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer-a prospective observation study

致编辑的信：放射治疗对难治性微卫星稳定型转移性结直肠癌患者接受呋喹替尼联合信迪利单抗治疗的影响——一项前瞻性观察研究

Letter to the editor: safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcinoma beyond up-to-seven criteria

致编辑的信：PD-1抑制剂（信迪利单抗）联合经动脉化疗栓塞术作为中晚期肝细胞癌患者初始治疗方案（超出七项标准）的安全性和有效性

Correspondence on 'Pembrolizumab hybrid dosing is non-inferior to flat dosing in advanced non-small cell lung cancer: a real-world, retrospective bicenter cohort study' by Smeenk et al

关于 Smeenk 等人发表的题为“在晚期非小细胞肺癌中，帕博利珠单抗混合给药方案不劣于固定剂量方案：一项真实世界回顾性双中心队列研究”的来信

Storage of the vital metal tungsten in a dominant SCFA-producing human gut microbe Eubacterium limosum and implications for other gut microbes

人体肠道优势短链脂肪酸产生菌——黏液真杆菌中重要金属钨的储存及其对其他肠道微生物的影响

I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation

晶体衍射数据质量评估中 I/σI 与 {Rmerg, Rmeas, Rpim, CC1/2} 的关系

Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway

miR-26a 通过抑制 LIMS1/ILK 通路对血管紧张素 II 诱发的慢性肾脏病小鼠模型中的心肾损伤的治疗作用

Macrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155

巨噬细胞衍生的外泌体通过递送 miR-155 促进管状上皮细胞端粒脆性和衰老