A TROP2-targeting ADC synergizes with oxidative phosphorylation inhibitor to enhance apoptosis in ESCC by suppressing the PI3K-AKT-mTOR signaling pathway.
靶向 TROP2 的 ADC 与氧化磷酸化抑制剂协同作用,通过抑制 PI3K-AKT-mTOR 信号通路增强食管鳞状细胞癌的细胞凋亡。
期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08278-5
Liu Xinxin, Liu Jie, Zhou Yi'an, Li Mei, Wang Feiqi, Jiang Guanfeng, Xiao Youban, Cui Wenming, Jiang Mingfeng, Gu Liang, Zhang Zuxiong, Zheng Yong, Zhang Shuyong
肿瘤
凋亡
表观遗传
肿瘤免疫
mTOR
信号转导
磷酸化
细胞生物学
AKT