A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis.
一种小分子 VDAC 配体通过破坏钙稳态抑制 ERAD 并诱导选择性癌细胞死亡。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-67816-z
Yan Wenjing, Talley Daniel C, Syam Antara, Danchik Carina, Zhong Yongwang, Zhang Xianzheng, Liu Xiaoying, Baljinnyam Bolormaa, Kales Stephen C, Cyr Matthew G, Fang Yuhong, Zakharov Alexey V, Hu Xin, Niehoff Taylor, Xu Tuan, Qu Yanyan, Yang Allison, Courouble Valentine V, Yao Qin, Simeonov Anton, Huang Ruili, Rostovtseva Tatiana K, Bezrukov Sergey M, LeClair Christopher A, Egan Josephine M, Wang Hua, Tao Dingyin, Rai Ganesha, Henderson Mark J, Fang Shengyun
