PARG inhibition suppresses breast cancer progression and potentiates immunoresponse through MTDH degradation mediated by E3 ligase ITCH-dependent ubiquitination.

PARG 抑制通过 E3 连接酶 ITCH 依赖性泛素化介导的 MTDH 降解来抑制乳腺癌进展并增强免疫反应。