日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective fluorination of Fc glycans enhances antibody-mediated effector functions

Fc糖链的选择性氟化可增强抗体介导的效应功能

Wang, Xianyang; Gomozkova, Margaryta; Li, Siqi; Banerjee, Biswarup; Zong, Guanghui; Missiakas, Dominique; Wang, Lai-Xi

N‑Azidoacetylglucosamine (GlcNAz)-Derived Sugar Oxazolines as a New Class of Substrates for Chemoenzymatic Site-Specific Antibody Bioconjugation

N-叠氮乙酰氨基葡萄糖(GlcNAz)衍生的糖噁唑啉作为化学酶法位点特异性抗体生物偶联的新型底物

Zong, Guanghui; Gomozkova, Margaryta; Azzam, Tala; Sundberg, Eric J; Wang, Lai-Xi

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria.

发现一种单亚基寡糖基转移酶,能够使细菌中的全长 IgG 抗体糖基化

Sotomayor Belen, Donahue Thomas C, Mahajan Sai Pooja, Taw May N, Hulbert Sophia W, Bidstrup Erik J, Owitipana D Natasha, Pang Alexandra, Yang Xu, Ghosal Souvik, Alabi Christopher A, Azadi Parastoo, Gray Jeffrey J, Jewett Michael C, Wang Lai-Xi, DeLisa Matthew P

Glycosylation of Structured Protein Domains in Cell-Free Reaction Environments.

无细胞反应环境中结构蛋白结构域的糖基化

Bidstrup Erik J, Hill Kyle, Bandi Chandra K, Owitipana D Natasha, Chisti Alina, Aw Rochelle, Yang Xu, Azadi Parastoo, Jewett Michael C, Wang Lai-Xi, Kightlinger Weston, DeLisa Matthew P

Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models

在小鼠模型中,免疫球蛋白G亚类通过不同的机制提供针对金黄色葡萄球菌血液播散的保护作用。

Chen, Xinhai; Gula, Haley; Pius, Tonu; Ou, Chong; Gomozkova, Margaryta; Wang, Lai-Xi; Schneewind, Olaf; Missiakas, Dominique

"Ghost" Fragment Ions in Structure and Site-Specific Glycoproteomics Analysis

结构和位点特异性糖蛋白组学分析中的“幽灵”碎片离子

Campos, Diana; Girgis, Michael; Yang, Qiang; Zong, Guanghui; Goldman, Radoslav; Wang, Lai-Xi; Sanda, Miloslav

Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions.

阳离子-阴离子囊泡作为展示天然 N-糖配体的简便支架,用于探测多价碳水化合物-凝集素相互作用

Donahue Thomas C, Zong Guanghui, Ou Chong, DeShong Philip, Wang Lai-Xi

Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9

合成的位点特异性抗体-配体偶联物促进去唾液酸糖蛋白受体介导的细胞外人PCSK9降解

Donahue, Thomas C; Ou, Chong; Yang, Qiang; Flinko, Robin; Zhang, Xiao; Zong, Guanghui; Lewis, George K; Wang, Lai-Xi

Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody-Drug Conjugates

两种化学酶法糖基化修饰方法在生成位点特异性抗体-药物偶联物中的应用评价

Yang, Qiang; Chen, He; Ou, Chong; Zheng, Zhihao; Zhang, Xiao; Liu, Yunpeng; Zong, Guanghui; Wang, Lai-Xi

"Ghost" fragment ions in structure and site-specific glycoproteomics analysis

结构和位点特异性糖蛋白组学分析中的“幽灵”碎片离子

Campos, Diana; Girgis, Michael; Yang, Qiang; Zong, Guanghui; Goldman, Radoslav; Wang, Lai-Xi; Sanda, Miloslav