日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.

B55α和Greatwall表达水平之间的平衡可以预测癌细胞对Greatwall抑制剂的敏感性

Zach Róbert, Annis Michael, Martin-Guerrero Sandra M, Alatawi Abdulrahman, Chia Kim Hou, Meredith Megan, Osborn Kay, Peter Nisha, Pearce William, Booth Jessica, Rajasekaran Mohan, Dias Samantha, Coleman-Evans Lily, Foster William R, Harper Jon A, Herbert Alex D, Tighe Catherine, Reuillon Tristan, West Ryan, Busby Oliver, Burdova Kamila, Crepin Damien, Ortoll Sergi, Vaeteewoottacharn Kulthida, Dejsuphong Donniphat, Spencer John, Patel Hitesh, Le Grand Darren, Hunt Thomas A, Andrews David M, Yamano Hiroyuki, Cutillas Pedro R, Oliver Antony W, Ward Simon E, Hochegger Helfrid

Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors

四氢吡唑并吡啶酮类化合物作为一类新型高效高选择性LIMK抑制剂

Baldwin, Alex G; Foley, David W; Jones, D Heulyn; Lee, Hyunah; Collins, Ross; Wahab, Ben; Pedder, Josephine H; Waters, Loren; Paine, Marie; Schino, Lauramariú; Feng, Gui Jie; Kariuki, Benson M; Elkins, Jonathan M; Atack, John R; Ward, Simon E

Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.

MDI-114215 的发现:一种强效且选择性的 LIMK 抑制剂,可用于治疗脆性 X 综合征

Baldwin Alex G, Foley David W, Collins Ross, Lee Hyunah, Jones D Heulyn, Wahab Ben, Waters Loren, Pedder Josephine, Paine Marie, Feng Gui Jie, Privitera Lucia, Ashall-Kelly Alexander, Thomas Carys, Gillespie Jason A, Schino Lauramariú, Belelli Delia, Rocha Cecilia, Maussion Gilles, Krahn Andrea I, Durcan Thomas M, Elkins Jonathan M, Lambert Jeremy J, Atack John R, Ward Simon E

How Do Gepotidacin and Zoliflodacin Stabilize DNA Cleavage Complexes with Bacterial Type IIA Topoisomerases? 1. Experimental Definition of Metal Binding Sites

吉泊他辛和佐利氟达辛如何稳定细菌IIA型拓扑异构酶的DNA切割复合物? 1. 金属结合位点的实验定义

Morgan, Harry; Nicholls, Robert A; Warren, Anna J; Ward, Simon E; Evans, Gwyndaf; Long, Fei; Murshudov, Garib N; Duman, Ramona; Bax, Benjamin D

Central Nervous System Targeted Protein Degraders

中枢神经系统靶向蛋白降解剂

Thomas, Bedwyr Ab Ion; Lewis, H Lois; Jones, D Heulyn; Ward, Simon E

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

酪氨酸121的移动暴露出一个配体结合口袋,该口袋将丝氨酸消旋酶的催化作用与ATP结合偶联起来。

Koulouris, Chloe R; Gardiner, Sian E; Harris, Tessa K; Elvers, Karen T; Mark Roe, S; Gillespie, Jason A; Ward, Simon E; Grubisha, Olivera; Nicholls, Robert A; Atack, John R; Bax, Benjamin D

Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

肝脏免疫微环境与结直肠癌转移——发病机制和治疗展望

Zeng, Xuezhen; Ward, Simon E; Zhou, Jingying; Cheng, Alfred S L

Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile

对新型AMPA受体正向变构调节剂MDI-222进行药理学表征,该调节剂具有更佳的安全性。

Ward, Simon E; Harries, Mark H; Aldegheri, Laura; Bradford, Andrea M; Ballini, Elisa; Dawson, Lee; Lacroix, Laurent; Pardoe, Joanne; Starr, Kathryn; Weil, Annette; Waters, Kerry; Atack, John R; Woolley, Marie

Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer

开发2-(4-吡啶基)-苯并咪唑类化合物作为PKN2化学工具用于癌症研究

Scott, Fiona; Fala, Angela M; Pennicott, Lewis E; Reuillon, Tristan D; Massirer, Katlin B; Elkins, Jonathan M; Ward, Simon E

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

温和条件下无金属选择性单卤代脱羧杂芳烃

Henderson, Scott H; West, Ryan A; Ward, Simon E; Honey, Mark A