日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15-GFRaL-RET Complex Cell Signaling

设计模拟同源二聚体GDF15蛋白的双环肽串联体以抑制GDF15-GFRaL-RET复合物细胞信号传导

Noisier, Anaïs F M; Sandmark, Jenny; Edfeldt, Fredrik; Backmark, Anna; Broddefalk, Johan; Wandzik, Joanna; Jurva, Ulrik; Ek, Margareta; Johansson, Carina A; Barlind, Louise; Gunnarsson, Jenny; Bigalke, Janna M; Xue, Yafeng; Frolov, Andrey I; Kankkonen, Cecilia; Roth, Robert G; Fritsch, Maria; Watcham, Sophie; van Rietschoten, Katerine; Mudd, Gemma E; Harrison, Helen; Chen, Liuhong; Skynner, Michael J; Craik, David J; Chankeshwara, Sunay V; Lemurell, Malin

A real-world test of artificial intelligence infiltration of a university examinations system: A "Turing Test" case study

人工智能渗透大学考试系统的真实案例测试:“图灵测试”案例研究

Scarfe, Peter; Watcham, Kelly; Clarke, Alasdair; Roesch, Etienne

Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes

白血病前期单细胞图谱揭示了突变特异性机制和基因程序,这些机制和程序可预测急性髓系白血病(AML)患者的预后。

Tomoya Isobe ,Iwo Kucinski ,Melania Barile ,Xiaonan Wang ,Rebecca Hannah ,Hugo P Bastos ,Shirom Chabra ,M S Vijayabaskar ,Katherine H M Sturgess ,Matthew J Williams ,George Giotopoulos ,Ludovica Marando ,Juan Li ,Justyna Rak ,Malgorzata Gozdecka ,Daniel Prins ,Mairi S Shepherd ,Sam Watcham ,Anthony R Green ,David G Kent ,George S Vassiliou ,Brian J P Huntly ,Nicola K Wilson ,Berthold Göttgens

BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors

BT8009;一种靶向Nectin-4的环状毒素偶联物,用于治疗实体瘤

Rigby, Michael; Bennett, Gavin; Chen, Liuhong; Mudd, Gemma E; Harrison, Helen; Beswick, Paul J; Van Rietschoten, Katerine; Watcham, Sophie M; Scott, Heather S; Brown, Amy N; Park, Peter U; Campbell, Carly; Haines, Eric; Lahdenranta, Johanna; Skynner, Michael J; Jeffrey, Phil; Keen, Nicholas; Lee, Kevin

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

调控微环境组成可限制疟原虫感染期间造血干细胞的损伤。

Haltalli, Myriam L R; Watcham, Samuel; Wilson, Nicola K; Eilers, Kira; Lipien, Alexander; Ang, Heather; Birch, Flora; Anton, Sara Gonzalez; Pirillo, Chiara; Ruivo, Nicola; Vainieri, Maria L; Pospori, Constandina; Sinden, Robert E; Luis, Tiago C; Langhorne, Jean; Duffy, Ken R; Göttgens, Berthold; Blagborough, Andrew M; Lo Celso, Cristina

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

两种醛类清除系统对于防止小鼠和人体内致命的甲醛积累至关重要。

Felix A Dingler ,Meng Wang ,Anfeng Mu ,Christopher L Millington ,Nina Oberbeck ,Sam Watcham ,Lucas B Pontel ,Ashley N Kamimae-Lanning ,Frederic Langevin ,Camille Nadler ,Rebecca L Cordell ,Paul S Monks ,Rui Yu ,Nicola K Wilson ,Asuka Hira ,Kenichi Yoshida ,Minako Mori ,Yusuke Okamoto ,Yusuke Okuno ,Hideki Muramatsu ,Yuichi Shiraishi ,Masayuki Kobayashi ,Toshinori Moriguchi ,Tomoo Osumi ,Motohiro Kato ,Satoru Miyano ,Etsuro Ito ,Seiji Kojima ,Hiromasa Yabe ,Miharu Yabe ,Keitaro Matsuo ,Seishi Ogawa ,Berthold Göttgens ,Michael R G Hodskinson ,Minoru Takata ,Ketan J Patel

The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production

在原发性血小板增多症小鼠模型中,干细胞/祖细胞格局发生重塑,导致巨核细胞过度生成。

Daniel Prins ,Hyun Jung Park ,Sam Watcham ,Juan Li ,Michele Vacca ,Hugo P Bastos ,Alexander Gerbaulet ,Antonio Vidal-Puig ,Berthold Göttgens ,Anthony R Green