日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

利用DILIsym进行定量系统毒理学建模,以支持Fezolinetant的III期剂量选择。

Nielsen, Jace C; Woodhead, Jeffrey L; Howell, Brett A; Shoda, Lisl K M; Parasrampuria, Dolly A; Huang, Jiayin; Iwai, Megumi; Ottery, Faith D; Wang, Xuegong; English, Marci; Miyazaki, Kentaro; Watkins, Paul B

A Phase 1 Dose-Escalation, Food Effect, and Drug-Drug Interaction Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MALT1 Inhibitor, SGR-1505, in Healthy Volunteers

一项评估 MALT1 抑制剂 SGR-1505 在健康志愿者中的安全性、耐受性、药代动力学和药效学的 1 期剂量递增、食物影响和药物相互作用研究

Gupta, Vipul K; Yoo, Brian; Weiss, Daniel; Basile, Frank G; Schuck, Edgar; Rubino, Christopher M; Zhang, Sen; Maxwell, Stephen E; Zheng, Wenxin; Tan, Joanne B L; Stenehjem, David; Watkins, Paul B; Dugan, Margaret; Yin, Wu; Wright, D Hamish; Akinsanya, Karen; Lickliter, Jason

Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities

托伐普坦在常染色体显性多囊肾病中的安全性;重点关注特异性药物性肝损伤风险

Hammond, Sean; Meng, Xiaoli; Barber, Jane; Mosedale, Merrie; Chadwick, Amy; Watkins, Paul B; Naisbitt, Dean J

Blood toxicogenomics reveals potential biomarkers for management of idiosyncratic drug-induced liver injury

血液毒理基因组学揭示了用于管理特异性药物性肝损伤的潜在生物标志物

Church, Rachel J; Anchang, Benedict; Bennett, Brian D; Bushel, Pierre R; Watkins, Paul B

ERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study

COVID-19 mRNA疫苗接种后肝损伤中ERAP-1和ERAP-2变体:一项美国多中心研究

Fontana, Robert J; Li, Yi Ju; Vuppalanchi, Raj; Kleiner, David E; Gu, Jiezhun; Shroff, Hersh; Van Wagner, Lisa B; Watkins, Paul B

Management of Select Adverse Events Following Delandistrogene Moxeparvovec Gene Therapy for Patients With Duchenne Muscular Dystrophy

杜氏肌营养不良症患者接受Delandistrogene Moxeparvovec基因治疗后特定不良事件的管理

Zaidman, Craig M; Goedeker, Natalie L; Aqul, Amal A; Butterfield, Russell J; Connolly, Anne M; Crystal, Ronald G; Godwin, Kara E; Hor, Kan N; Mathews, Katherine D; Proud, Crystal M; Kula Smyth, Elizabeth; Veerapandiyan, Aravindhan; Watkins, Paul B; Mendell, Jerry R

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate

ERAP2表达降低和一种新的HLA等位基因的鉴定,可作为阿莫西林-克拉维酸钾引起肝损伤易感性风险评分的组成部分

Nicoletti, Paola; Dellinger, Andrew; Li, Yi Ju; Barnhart, Huiman X; Chalasani, Naga; Fontana, Robert J; Odin, Joseph A; Serrano, Jose; Stolz, Andrew; Etheridge, Amy S; Innocenti, Federico; Govaere, Olivier; Grove, Jane I; Stephens, Camilla; Aithal, Guruprasad P; Andrade, Raul J; Bjornsson, Einar S; Daly, Ann K; Lucena, M Isabel; Watkins, Paul B

An approach for collaborative development of a federated biomedical knowledge graph-based question-answering system: Question-of-the-Month challenges

一种基于联邦生物医学知识图谱的问答系统协作开发方法:每月一问挑战

Fecho, Karamarie; Bizon, Chris; Issabekova, Tursynay; Moxon, Sierra; Thessen, Anne E; Abdollahi, Shervin; Baranzini, Sergio E; Belhu, Basazin; Byrd, William E; Chung, Lawrence; Crouse, Andrew; Duby, Marc P; Ferguson, Stephen; Foksinska, Aleksandra; Forero, Laura; Friedman, Jennifer; Gardner, Vicki; Glusman, Gwênlyn; Hadlock, Jennifer; Hanspers, Kristina; Hinderer, Eugene; Hobbs, Charlotte; Hyde, Gregory; Huang, Sui; Koslicki, David; Mease, Philip; Muller, Sandrine; Mungall, Christopher J; Ramsey, Stephen A; Roach, Jared; Rubin, Irit; Schurman, Shepherd H; Shalev, Anath; Smith, Brett; Soman, Karthik; Stemann, Sarah; Su, Andrew I; Ta, Casey; Watkins, Paul B; Williams, Mark D; Wu, Chunlei; Xu, Colleen H

FRI017 Precision-engineered Activin And GDF Ligand Trap HS235: A Novel Lean Mass-preserving Treatment for Obesity

FRI017 精密设计的激活素和 GDF 配体捕获剂 HS235:一种新型的肥胖症瘦体重维持疗法

Urban, Thomas J; Goldstein, David B; Watkins, Paul B; Schang, Gauthier; de Molliens, Mathilde Poujol; Brûlé, Emilie; Chauvet, Cristina; Denis, Jean-François; Sours, Ariane; Ganesh, Vannakambadi; Tremblay, Gilles; Schoelermann, Julia; O'Connor-McCourt, Maureen

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

利用多药耐药蛋白3 (MDR3) 抑制的机制模型研究胆汁酸介导的胆汁淤积性药物性肝损伤

Beaudoin, James J; Yang, Kyunghee; Adiwidjaja, Jeffry; Taneja, Guncha; Watkins, Paul B; Siler, Scott Q; Howell, Brett A; Woodhead, Jeffrey L