文献库，生知库 | 链接生命科学的每一步

日期影响因子

The Protein Tyrosine Phosphatase 1B Modulates the Activation of Yes-Associated Protein and Sensitizes to Cytotoxic Chemotherapy in Preclinical Models of Cholangiocarcinoma.

蛋白酪氨酸磷酸酶 1B 调节 Yes 相关蛋白的激活，并在胆管癌临床前模型中增强对细胞毒性化疗的敏感性。

影响因子:5.2

doi:10.3390/cells14191560

Watkins Ryan D, Tomlinson Jennifer L, Buckarma EeeLN H, Kuipers Hendrien, Carlson Danielle M, Werneburg Nathan W, O'Brien Daniel R, Wang Chen, Smoot Rory L

细胞生物学

发表日期：2025

文献求助收藏

The oncogenic potential of YAP requires Y357 phosphorylation in cholangiocytes but not in hepatocytes.

YAP 的致癌潜力需要胆管细胞中的 Y357 磷酸化，但不需要肝细胞中的 Y357 磷酸化。

期刊:Cellular Oncology

影响因子:4.8

doi:10.1007/s13402-025-01133-x

Aksu Muhammed Dogukan, Millender Jayla T, McCabe Chantal E, Watkins Ryan D, Yonkus Jennifer A, Buckarma EeeLN H, Werneburg Nathan W, O'Brien Daniel R, Graham Rondell P, Gores Gregory J, Smoot Rory L, Conboy Caitlin B

细胞生物学

发表日期：2025

文献求助收藏

Syngeneic murine models with distinct immune microenvironments represent subsets of human intrahepatic cholangiocarcinoma

具有不同免疫微环境的同源小鼠模型代表了人类肝内胆管癌的亚型。

期刊:Journal of Hepatology

影响因子:33

doi:10.1016/j.jhep.2024.02.008

Tomlinson, Jennifer L; Li, Binbin; Yang, Jingchun; Loeuillard, Emilien; Stumpf, Hannah E; Kuipers, Hendrien; Watkins, Ryan; Carlson, Danielle M; Willhite, Jessica; O'Brien, Daniel R; Graham, Rondell P; Chen, Xin; Smoot, Rory L; Dong, Haidong; Gores, Gregory J; Ilyas, Sumera I

免疫/内分泌

发表日期：2024

文献求助收藏

Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism

人工智能发现引擎针对参与淋病奈瑟菌肽聚糖代谢的酶识别的化合物的抗菌活性

期刊:Biological Research

影响因子:4.3

doi:10.1186/s40659-024-00543-9

Ravi Kant #, Hannah Tilford #, Camila S Freitas, Dayana A Santos Ferreira, James Ng, Gwennan Rucinski, Joshua Watkins, Ryan Pemberton, Tigran M Abramyan, Stephanie C Contreras, Alejandra Vera, Myron Christodoulides

发表日期：2024

文献求助收藏

A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis.

小分子 MST1/2 抑制剂可加速小鼠肝脏再生，提高脂肪性肝炎模型小鼠的存活率

期刊:PNAS Nexus

影响因子:3.8

doi:10.1093/pnasnexus/pgae096

Watkins Ryan, Gamo Ana, Choi Seung Hyuk, Kumar Manoj, Buckarma EeeLN, McCabe Chantal, Tomlinson Jennifer, Pereya David, Lupse Blaz, Geravandi Shirin, Werneburg Nathan W, Wang Chen, Starlinger Patrick, Zhu Siying, Li Sijia, Yu Shan, Surakattula Murali, Baguley Tyler, Ardestani Amin, Maedler Kathrin, Roland Jason, Nguyen-Tran Van, Joseph Sean, Petrassi Mike, Rogers Nikki, Gores Gregory, Chatterjee Arnab, Tremblay Matthew, Shen Weijun, Smoot Rory

免疫/内分泌

发表日期：2024

文献求助收藏

Mediastinitis after endobronchial ultrasound with transbronchial needle aspiration resulting in postpneumonectomy empyema

经支气管超声引导下经支气管针吸活检术后纵隔炎导致肺切除术后脓胸

doi:10.1016/j.xjtc.2024.03.012

Robinson, Nathaniel L; Watkins, Ryan D; Tapias, Luis F

发表日期：2024

文献求助收藏

Neoadjuvant therapy leads to objective response in intrahepatic cholangiocarcinoma

新辅助治疗可使肝内胆管癌患者获得客观缓解

doi:10.1016/j.hpb.2024.04.003

Van Treeck, Benjamin J; Olave, Maria C; Watkins, Ryan D; Lu, Haiyan; Moreira, Roger K; Mounajjed, Taofic; Johnson, Michael J; Smith, Carin Y; Ilyas, Sumera I; Tran, Nguyen H; Jenkins, Sarah M; Reed, Katelyn A; Smoot, Rory; Mahipal, Amit; Allende, Daniela; Graham, Rondell P

发表日期：2024

文献求助收藏

Tyrosine phosphorylation of YAP-1 in biliary epithelial cells mediates posthepatectomy liver regeneration and is affected by serotonin

胆管上皮细胞中YAP-1的酪氨酸磷酸化介导肝切除术后肝脏再生，并受血清素的影响。

期刊:Journal of Cellular Biochemistry

影响因子:2.8

doi:10.1002/jcb.30398

Starlinger, Patrick; Brunnthaler, Laura; Watkins, Ryan; Pereyra, David; Stift, Judith; Finsterbusch, Michaela; Santol, Jonas; Gruenberger, Thomas; Assinger, Alice; Smoot, Rory

细胞生物学

发表日期：2023

文献求助收藏

Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking

Toll 样受体 4 拮抗剂可减少可卡因引发的药物寻求行为的恢复

期刊:Psychopharmacology

doi:10.1007/s00213-023-06392-w

Kyle T Brown, Sophia C Levis, Casey E O'Neill, Catherine Levy, Kenner C Rice, Linda R Watkins, Ryan K Bachtell

Toll-Like Receptor

发表日期：2023

文献求助收藏

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

8-oxoG 的全局性和转录偶联修复由核苷酸切除修复蛋白启动。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-022-28642-9

Namrata Kumar ,Arjan F Theil ,Vera Roginskaya ,Yasmin Ali ,Michael Calderon ,Simon C Watkins ,Ryan P Barnes ,Patricia L Opresko ,Alex Pines ,Hannes Lans ,Wim Vermeulen ,Bennett Van Houten

发表日期：2022

文献求助收藏