日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Haplotype editing with CRISPR-Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL

利用 CRISPR-Cas9 进行单倍型编辑作为治疗 NEFL 中显性负性错义突变的治疗方法

Dua, Poorvi H; Simon, Bazilco M J; Marley, Chiara B E; Feliciano, Carissa M; Watry, Hannah L; Cowan, Quinn T; Steury, Dylan; Abraham, Abin; Gilbertson, Erin N; Ramey, Grace D; Capra, John A; Conklin, Bruce R; Judge, Luke M

Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles

利用人类遗传变异,以治疗为目标,靶向数百个具有显性和非显性致病等位基因的基因。

Ramey, Grace D; Cowan, Quinn T; Saxena, Akshita G; Macklin, Bria L; Watry, Hannah L; Mei, Xiaoyue; Dierks, Philip; Judge, Luke M; Conklin, Bruce R; Capra, John A

Functional analysis of a common BAG3 allele associated with protection from heart failure.

对与预防心力衰竭相关的常见 BAG3 等位基因进行功能分析

Perez-Bermejo Juan A, Judge Luke M, Jensen Christina L, Wu Kenneth, Watry Hannah L, Truong Annie, Ho Jaclyn J, Carter Matthew, Runyon Wendy V, Kaake Robyn M, Pulido Ernst H, Mandegar Mohammad A, Swaney Danielle L, So Po-Lin, Krogan Nevan J, Conklin Bruce R

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

利用 DISCOVER-Seq 技术在体内进行无偏 CRISPR 脱靶效应检测

Wienert, Beeke; Wyman, Stacia K; Richardson, Christopher D; Yeh, Charles D; Akcakaya, Pinar; Porritt, Michelle J; Morlock, Michaela; Vu, Jonathan T; Kazane, Katelynn R; Watry, Hannah L; Judge, Luke M; Conklin, Bruce R; Maresca, Marcello; Corn, Jacob E