日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties.

探索组蛋白去乙酰化酶 (HDAC) 抑制剂中的替代锌结合基团，发现 DS-103 是一种具有化学增敏特性的强效乙基肼基 HDAC 抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c02373
Stopper Daniel, Biermann Lukas, Watson Paris R, Li Jingyu, König Beate, Gaynes Matthew N, Pessanha de Carvalho Lais, Klose Jana, Hanl Maria, Hamacher Alexandra, Schäker-Hübner Linda, Ramsbeck Daniel, Held Jana, Christianson David W, Kassack Matthias U, Hansen Finn K
其它
乙酰化
发表日期：2025
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Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

利用非经典氨基酸诱变技术研究α-突触核蛋白中所有与疾病相关的赖氨酸乙酰化位点

期刊:
影响因子:
doi:10.1101/2025.01.21.634178
Shimogawa, Marie; Li, Ming-Hao; Park, Grace Shin Hye; Ramirez, Jennifer; Lee, Hudson; Watson, Paris R; Sharma, Swati; Lin, Zongtao; Peng, Chao; Lee, Virginia M-Y; Garcia, Benjamin A; Christianson, David W; Rhoades, Elizabeth; Eliezer, David; Petersson, E James
乙酰化
表观遗传
神经科学
发表日期：2025
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Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10

HDAC10乙酰化苯硫酮抑制剂的设计、合成和结构评价

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.4c00293
Goulart Stollmaier, Juana; Watson, Paris R; Christianson, David W
乙酰化
表观遗传
HDAC1
发表日期：2024
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Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism.

组蛋白去乙酰化酶 6 与 (R)-硫辛酸（中心碳代谢中的一种重要辅因子）复合物的晶体结构

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2023.105228
Watson Paris R, Stollmaier Juana Goulart, Christianson David W
代谢
乙酰化
发表日期：2023
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Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6

大环八肽结合及其对组蛋白去乙酰化酶 6 蛋白质底物结合的推断

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.3c00113
Watson, Paris R; Gupta, Suchetana; Hosseinzadeh, Parisa; Brown, Benjamin P; Baker, David; Christianson, David W
乙酰化
表观遗传
发表日期：2023
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Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii

多重耐药病原体鲍曼不动杆菌的 II 类脱乙酰酶 Kdac1 的结构和功能

期刊:Biochemistry
影响因子:3
doi:10.1021/acs.biochem.3c00288
Watson, Paris R; Christianson, David W
微生物学
发表日期：2023
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Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

锚定延伸：一种以结构为导向的环肽设计方法，靶向酶活性位点

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-021-23609-8
Hosseinzadeh, Parisa; Watson, Paris R; Craven, Timothy W; Li, Xinting; Rettie, Stephen; Pardo-Avila, Fátima; Bera, Asim K; Mulligan, Vikram Khipple; Lu, Peilong; Ford, Alexander S; Weitzner, Brian D; Stewart, Lance J; Moyer, Adam P; Di Piazza, Maddalena; Whalen, Joshua G; Greisen, Per Jr; Christianson, David W; Baker, David
发表日期：2021
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Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype

与组蛋白去乙酰化酶 6 催化通道的独特分子相互作用：模型化学类型的晶体学和生物学表征

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.0c01922
Olaoye, Olasunkanmi O; Watson, Paris R; Nawar, Nabanita; Geletu, Mulu; Sedighi, Abootaleb; Bukhari, Shazreh; Raouf, Yasir S; Manaswiyoungkul, Pimyupa; Erdogan, Fettah; Abdeldayem, Ayah; Cabral, Aaron D; Hassan, Muhammad Murtaza; Toutah, Krimo; Shouksmith, Andrew E; Gawel, Justyna M; Israelian, Johan; Radu, Tudor B; Kachhiyapatel, Niyati; de Araujo, Elvin D; Christianson, David W; Gunning, Patrick T
乙酰化
表观遗传
发表日期：2021
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