日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile

在siRNA种子区对siRNA骨架进行单烷基膦酸酯修饰可增强其特异性和治疗效果。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf692
Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W Brad; Watt, Andrew T; Migawa, Michael T; Swayze, Eric E; Prakash, Thazha P
发表日期：2025
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Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy

Gapmer反义寡核苷酸的非特异性活性可能性与相对杂交自由能相关。

期刊:Nucleic Acid Therapeutics
影响因子:4.7
doi:10.1089/nat.2020.0847
Watt, Andrew T; Swayze, Grant; Swayze, Eric E; Freier, Susan M
发表日期：2020
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Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.

利用反义寡核苷酸对突变亨廷顿蛋白进行等位基因特异性抑制：为所有亨廷顿病患者提供治疗选择

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0107434
Skotte Niels H, Southwell Amber L, Østergaard Michael E, Carroll Jeffrey B, Warby Simon C, Doty Crystal N, Petoukhov Eugenia, Vaid Kuljeet, Kordasiewicz Holly, Watt Andrew T, Freier Susan M, Hung Gene, Seth Punit P, Bennett C Frank, Swayze Eric E, Hayden Michael R
免疫/内分泌
发表日期：2014
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.

合理设计针对单核苷酸多态性的反义寡核苷酸，以有效且有等位基因选择性地抑制中枢神经系统中的突变亨廷顿蛋白

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkt725
Østergaard Michael E, Southwell Amber L, Kordasiewicz Holly, Watt Andrew T, Skotte Niels H, Doty Crystal N, Vaid Kuljeet, Villanueva Erika B, Swayze Eric E, Bennett C Frank, Hayden Michael R, Seth Punit P
神经科学
发表日期：2013
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Control of RNA processing by a large non-coding RNA over-expressed in carcinomas.

癌细胞中过度表达的大型非编码RNA控制RNA加工

期刊:FEBS Letters
影响因子:3
doi:10.1016/j.febslet.2011.01.030
Lin Rui, Roychowdhury-Saha Manami, Black Chris, Watt Andrew T, Marcusson Eric G, Freier Susan M, Edgington Thomas S
细胞生物学
肿瘤免疫
发表日期：2011
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An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA

环外亚甲基作为LNA中2'-氧原子的生物等排体。

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/ja105875e
Seth, Punit P; Allerson, Charles R; Berdeja, Andres; Siwkowski, Andrew; Pallan, Pradeep S; Gaus, Hans; Prakash, Thazha P; Watt, Andrew T; Egli, Martin; Swayze, Eric E
发表日期：2010
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