日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence

人类MASLD中的进行性纤维化与代谢重编程和衰老的空间关联转录组特征有关

Vu, Hani; Sun, Yuliangzi; Xiong, Zherui; Tan, Xiao; Radford-Smith, Daniel; Causer, Andrew; Dickens, Alex M; Hyötyläinen, Tuulia; Evstafev, Ilia; Oresic, Matej; Nefzger, Christian; O'Sullivan, Eoin D; Watt, Matthew J; Ramm, Grant A; Clouston, Andrew; Irvine, Katharine M; Nguyen, Quan H; Powell, Elizabeth E

Effect of free fatty acids on TGF-β1 mediated fibrogenesis in hepatic stellate cells.

游离脂肪酸对肝星状细胞中 TGF-β1 介导的纤维化的影响。

De Nardo William, Bayliss Jacqueline, Elahee Doomun Sheik Nadeem, Lee Olivia, Miotto Paula M, Suriani Natasha D, Nie Shuai, Leeming Michael, Miranda Diego A, De Souza David P, Watt Matthew J

Global molecular landscape of early MASLD progression in human obesity

人类肥胖症早期MASLD进展的全球分子图谱

Zhao, Qing; De Nardo, William; Wang, Ruoyu; Zhong, Yi; Keles, Umur; Sakalauskaite, Gabriele; Zhao, Li Na; Tay, Huiyi; Youhanna, Sonia; Yan, Mengchao; Xie, Ye; Kim, Youngrae; Lee, Sungdong; Lim, Rachel Liyu; Teo, Guoshou; Narayanaswamy, Pradeep; Burton, Paul R; Lauschke, Volker M; Choi, Hyungwon; Watt, Matthew J; Kaldis, Philipp

Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator.

老年胰岛素抵抗骨骼的磷酸化蛋白质组学研究发现,AFF4 的 P70S6K 磷酸化是一种基因特异性转录调节因子。

Dutt Mriga, Liao Luoping, Kim Hani Jieun, Blazev Ronnie, Chan Audrey, Kore Hitesh, Bezawork-Geleta Ayenachew, Dong Li, Rivera Isela Sarahi, Wee Natalie K Y, Molendijk Jeffrey, Wong Julian P H, Haynes Vanessa R, Uribe Veronica, Lynch Gordon S, Smith Kelly A, Montgomery Magdalene K, Watt Matthew J, Yang Pengyi, Dodd Garron T, Vervoort Stephin J, Sims Natalie A, Parker Benjamin L

Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH.

整合肝脏分泌蛋白和血浆蛋白组学,建立了一个对 MASH 进行分层的预测模型

De Nardo William, Lee Olivia, Johari Yazmin, Bayliss Jacqueline, Pensa Marcus, Miotto Paula M, Keenan Stacey N, Ryan Andrew, Rucinski Amber, Svinos Tessa M, Ooi Geraldine J, Brown Wendy A, Kemp William, Roberts Stuart K, Parker Benjamin L, Montgomery Magdalene K, Larance Mark, Burton Paul R, Watt Matthew J

HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes.

HEXA-FC 蛋白疗法可增加骨骼肌葡萄糖摄取,改善胰岛素抵抗小鼠和 2 型糖尿病小鼠模型的血糖控制

Montgomery Magdalene K, Lin Sihan, Yang Chieh-Hsin, Prasad Krishneel, Cheng Zhi Li, Bayliss Jacqueline, Leeming Michael G, Williamson Nicholas A, Loh Kim, Dong Li, Watt Matthew J

HSD17β11 regulates PLIN5-ATGL mediated lipolysis, but not hepatic lipid metabolism in mice

HSD17β11 调节 PLIN5-ATGL 介导的脂肪分解,但不调节小鼠肝脏脂质代谢。

Keenan, Stacey N; Suriani, Natasha D; Fidelito, Gio; Bayliss, Jackie; Lou, Jieqiong; Solano, Ashleigh N; Sacharz, Joanna; Stroud, David A; Bezawork-Geleta, Ayenachew; Ooi, Geraldine; Burton, Paul R; Hinde, Elizabeth; Watt, Matthew J

Ubiquitous expression of an activating mutation in the Pik3ca gene reprograms glucose and lipid metabolism in mice.

Pik3ca 基因中激活突变的普遍表达可重编程小鼠的葡萄糖和脂质代谢

Caiazzo Sabrina, Watt Matthew J, Dodd Garron T, Bayliss Jacqueline, Thomas Helen, Smith Lorey K, Mitchell Camilla B, Phillips Wayne A

Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy

针对糖皮质激素在肌营养不良症中产生不良反应的机制基础的初步研究

Lloyd, Erin M; Crew, Rachael C; Haynes, Vanessa R; White, Robert B; Mark, Peter J; Jackaman, Connie; Papadimitriou, John M; Pinniger, Gavin J; Murphy, Robyn M; Watt, Matthew J; Grounds, Miranda D

Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity

线粒体和NOX4依赖性抗氧化防御机制可减轻肥胖患者非酒精性脂肪性肝炎的进展。

Greatorex, Spencer; Kaur, Supreet; Xirouchaki, Chrysovalantou E; Goh, Pei K; Wiede, Florian; Genders, Amanda J; Tran, Melanie; Jia, YaoYao; Raajendiran, Arthe; Brown, Wendy A; McLean, Catriona A; Sadoshima, Junichi; Watt, Matthew J; Tiganis, Tony