日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I

USP22 通过 EZH2 介导的 MHC-I 表观遗传沉默驱动肿瘤免疫逃逸和免疫检查点阻断耐药。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI193162
Liu, Kun; Iyer, Radhika; Li, Yi; Zhu, Jun; Cai, Zhaomeng; Wei, Juncheng; Cheng, Yang; Tang, Amy Y; Wang, Hai; Gao, Qiong; Mani, Nikita Lavanya; Marx, Noah; Gao, Beixue; Watterson, D Martin; Khan, Seema A; Gradishar, William J; Liu, Huiping; Fang, Deyu
肿瘤
表观遗传
肿瘤免疫
EZH2
免疫/内分泌
发表日期：2026
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Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy

确定 p38 MAPK 抑制作为 SMA 联合治疗的神经保护策略

期刊:EMBO Molecular Medicine
影响因子:8.3
doi:10.1038/s44321-025-00303-6
Carlini, Maria J; Espinoza-Derout, Jorge; Van Alstyne, Meaghan; Tisdale, Sarah; Workman, Eileen; Triplett, Marina K; Tattoli, Ivan; Yadav, Shubhi; Henderson, Christopher E; Watterson, D Martin; Pellizzoni, Livio
p38 MAPK
MAPK/ERK
发表日期：2025
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Optimized 5-HT(2b) inhibitors for neuropsychiatric syndromes with cognitive dysfunction

针对伴有认知功能障碍的神经精神综合征的优化型 5-HT(2b) 抑制剂

期刊:Alzheimer's and Dementia: Translational Research and Clinical Interventions
影响因子:6.8
doi:10.1002/trc2.70073
Roy, Saktimayee M; Acquarone, Erica; Argyrousi, Elentina K; Zhang, Hong; Staniszewski, Agnieszka; Inoue, Asuka; Ziarek, Joshua J; Arancio, Ottavio; Watterson, D Martin
5-HT
神经科学
发表日期：2025
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Discovery of small molecule candidate therapeutics against neuroimmune targets in Alzheimer’s disease

发现针对阿尔茨海默病神经免疫靶点的小分子候选疗法

期刊:Neurocritical Care
影响因子:3.6
doi:10.1007/s12028-022-01552-w
Islam, Rezwanul; Vrionis, Frank; Hanafy, Khalid A; Eldik, Linda Jo Van; Roy, Saktimayee M; Arancio, Ottavio; Watterson, D Martin
阿尔茨海默症
免疫/内分泌
发表日期：2025
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The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction

阿尔茨海默病中的5HT2b受体：患者脑内水平升高及拮抗剂可减轻淀粉样蛋白和tau蛋白诱导的功能障碍

期刊:Journal of Alzheimers Disease
影响因子:3.1
doi:10.3233/JAD-240063
Acquarone, Erica; Argyrousi, Elentina K; Arancio, Ottavio; Watterson, D Martin; Roy, Saktimayee M
信号转导
阿尔茨海默症
神经科学
发表日期：2024
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Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.

Stasimon 会导致脊髓性肌萎缩症小鼠模型中的感觉突触丢失和运动神经元死亡

期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2019.11.058
Simon Christian M, Van Alstyne Meaghan, Lotti Francesco, Bianchetti Elena, Tisdale Sarah, Watterson D Martin, Mentis George Z, Pellizzoni Livio
神经科学
Mouse
发表日期：2019
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A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

一种选择性强、可穿透血脑屏障的p38αMAPK抑制剂，有望用于治疗神经系统和神经精神疾病，并能减轻神经炎症和认知功能障碍。

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.9b00058
Roy, Saktimayee M; Minasov, George; Arancio, Ottavio; Chico, Laura W; Van Eldik, Linda J; Anderson, Wayne F; Pelletier, Jeffrey C; Watterson, D Martin
炎症
血脑屏障
炎症/感染
神经科学
MAPK/ERK
神经炎症
p38α
发表日期：2019
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Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia

肌球蛋白轻链激酶（MLCK210）基因敲除可预防血管性认知障碍和痴呆小鼠模型中的脑微出血并减轻神经炎症

期刊:Geroscience
影响因子:5.4
doi:10.1007/s11357-019-00072-4
Braun, David J; Bachstetter, Adam D; Sudduth, Tiffany L; Wilcock, Donna M; Watterson, D Martin; Van Eldik, Linda J
炎症
炎症/感染
信号转导
LCK
神经科学
神经炎症
发表日期：2019
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111 Changes in proinflammatory cytokines and chemokines in beef steers chronically exposed to endophyte-infected tall fescue seed

111 长期暴露于内生真菌感染的高羊茅种子的肉牛体内促炎细胞因子和趋化因子的变化

期刊:Journal of Interferon and Cytokine Research
影响因子:1.8
doi:10.1089/jir.2015.0115
Da Silva, Diane M; Woodham, Andrew W; Naylor, Paul H; Egan, James E; Berinstein, Neil L; Kast, W Martin; Eldik, Linda Jo Van; Roy, Saktimayee M; Arancio, Ottavio; Watterson, D Martin; Brown, Alecia R; Poole, Rebecca K; Jackson, McKenzie Lane; Poore, Matthew H; Pickworth, Carrie L; Poole, Daniel H
炎症/感染
细胞生物学
免疫/内分泌
微生物学
发表日期：2019
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p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

p38α MAPK信号通路驱动SERT Ala56小鼠出现药理学可逆的脑和胃肠道表型。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1809137115
Robson, Matthew J; Quinlan, Meagan A; Margolis, Kara Gross; Gajewski-Kurdziel, Paula A; Veenstra-VanderWeele, Jeremy; Gershon, Michael D; Watterson, D Martin; Blakely, Randy D
信号转导
p38α
MAPK/ERK
神经科学
发表日期：2018
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