RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors
RTx-303,一种口服生物利用度高的Polθ聚合酶抑制剂,可增强PARP抑制剂在BRCA突变肿瘤中的疗效
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00551.
Gurushankar Chandramouly ,William Fried ,John Gordon ,Douglas Ralph ,Channita Keuk ,Sangeeta Kumari ,Mercy Ramanjulu ,William Auerbacher ,Leonid Minakhin ,Taylor Tredinnick ,Bernadette Tiberi ,George Morton ,Robert Betsch ,Kathy Q Cai ,Umeshkumar M Vekariya ,Mrityunjay Tyagi ,Tomasz Skorski ,Sergey Karakashev ,Neil Johnson ,Wayne E Childers Jr ,Xiaojiang S Chen ,Richard T Pomerantz