日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Adenine base editor for knockout of proteins: A practical guide from design to analysis with updated MultiEditRbatch

用于蛋白质敲除的腺嘌呤碱基编辑器:从设计到分析的实用指南(含更新版 MultiEditRbatch)

Eaton, Ella J; Wick, Bryce J; Chacón, Jeremy S; Wang, Amy J; Kluesner, Mitchell; Barnes, Jackson T; Kar, Bibekananda; Wang, Minjing; Johnson, Matthew J; Skeate, Joseph G; Webber, Beau R; Moriarity, Branden S

Correction: Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks

更正:观点:IL-15细胞因子修饰的NK细胞作为多种恶性肿瘤的即用型免疫疗法:治疗潜力和毒性风险

Baughan, Scott L; Folsom, Timothy; Johnson, Matt; Kreuger, Joshua; Webber, Beau R; Moriarity, Branden S

Midgestational injection of highly expanded human CD34+ cells increases lineages of human immune cells and supports thymic development in RAG2-/-IL2RG-/Y SCID pigs.

在 RAG2-/-IL2RG-/Y SCID 猪的妊娠中期注射高度扩增的人类 CD34+ 细胞可增加人类免疫细胞谱系,并支持胸腺发育。

Forster Ahlea M, Kress Amanda Ahrens, Kiupel Matti, Cunnick Joan, Webster Dennis A, Campbell Jarryd M, Watson Adrienne L, Gafni Ohad, Carlson Daniel F, Moriarity Branden S, Webber Beau R, Napiwocki Brett, Daharsh Lance, Ross Jason W, Sauer Mary B, Tuggle Christopher K

Non-viral TcBuster transposon engineering of CD70-CAR natural killer cells for the treatment of osteosarcoma.

利用非病毒 TcBuster 转座子工程改造 CD70-CAR 自然杀伤细胞,用于治疗骨肉瘤。

Robbins Gabrielle M, Chang Jae-Woong, Krueger Joshua B, Vue Young Y, Gilkey Alexandria K, Folsom Timothy D, Jubenville Tyler, Skeate Joseph G, Langworthy Benjamin W, Fitzgerald Katelyn M, Peterson Joseph J, Stelljes Erin M, Largaespada David A, Rahrmann Eric P, Webber Beau R, Moriarity Branden S

Engineering "physically optimized" T cells for increased sampling of complex tumor microenvironments

通过工程手段对T细胞进行“物理优化”,以增加对复杂肿瘤微环境的采样。

Zhang, Hongrong; Chen, Zhongming; Qian, Guhan; Zahm, Christopher D; Alonso-Matilla, Roberto; Fischer, Salena; Stromnes, Ingunn M; Webber, Beau R; Eliceiri, Kevin W; Odde, David J; Moriarity, Branden S; Provenzano, Paolo P

Mechanistic modeling predicts efficacy of CISH knockout in tumor-infiltrating lymphocytes with synergistic gene editing

机制模型预测,CISH敲除在肿瘤浸润淋巴细胞中具有协同基因编辑的疗效。

Memmos, Nikolaos; Kaveh, Kamran; Moriarity, Branden; Webber, Beau R; Odde, David J

Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4+ T cells

白血病通过对新抗原特异性CD4+ T细胞施加1型调控程序来逃避免疫攻击。

Venkatesh, Hrishi; Granados Centeno, Enoc; Luo, Qianyun; Arroyo, Miriam; Heltemes-Harris, Lynn; Knutson, Todd P; Qiu, Yinjie; Haaning, Allison; Webber, Beau R; Bachanova, Veronika; Farrar, Michael A; Tracy, Sean I

Genetic engineering and allogeneic optimization of Vδ1 γδ CAR-T cells (ADI-270) for cancer immunotherapy

利用基因工程和同种异体优化技术改造Vδ1 γδ CAR-T细胞(ADI-270)用于癌症免疫治疗

Liu, Wenlong; Moriarity, Branden S; Webber, Beau R

Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing.

通过非病毒工程和高通量碱基编辑实现CAR-NK细胞的精确增强

Wang Minjing, Krueger Joshua B, Gilkey Alexandria K, Stelljes Erin M, Kluesner Mitchell G, Pomeroy Emily J, Skeate Joseph G, Slipek Nicholas J, Lahr Walker S, Claudio Vázquez Patricia N, Zhao Yueting, Bell Jason B, Clement Kendell, Eaton Ella J, Laoharawee Kanut, Chang Jae-Woong, Webber Beau R, Moriarity Branden S

Installation of Dominant-Negative Mutations in FAS and TGFβR2 via Base Editing in Primary T Cells.

通过碱基编辑在原代 T 细胞中引入 FAS 和 TGFβR2 的显性负突变。

Wick Bryce J, Kluesner Mitchell G, Slipek Nicholas J, Skeate Joseph G, Niemeyer Ethan M, Webber Beau R, Moriarity Branden S