日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-activity relationship profiling of N-substituted 8-trifluoromethyl-9H-purin-6-amines as mitochondrial protonophores

N-取代的8-三氟甲基-9H-嘌呤-6-胺作为线粒体质子载体的构效关系分析

Krinos, Emily L; Fields, Rei J; DeLuca, Isabella M; Foutz, Mary A; Li, Catherine; Hargett, Stefan R; Beretta, Martina; Zhou, Mingyan; Shrestha, Riya; Gwinn, Reilly K; Byrne, Frances L; Hoehn, Kyle L; Santos, Webster L

Substituted 1-(benzo[d]thiazol-2-yl)-3-phenylurea derivatives as anti-invasion agents

取代的1-(苯并[d]噻唑-2-基)-3-苯基脲衍生物作为抗入侵剂

Gwinn, Reilly K; Mannangatti, Padmanabhan; Mir, Shahid Maqbool; Kumari, Shikha; Le, Mai K; Das, Swadesh K; Fisher, Paul B; Santos, Webster L

Assessment of Spinster homologue 2 (Spns2)-dependent transport of sphingosine-1-phosphate as a therapeutic target.

评估 Spinster 同源物 2 (Spns2) 依赖的鞘氨醇-1-磷酸转运作为治疗靶点

Kharel Yugesh, Huang Tao, Dunnavant Kyle, Foster Daniel, Souza George M P R, Nimchuk Katherine E, Merchak Andrea R, Pavelec Caitlin M, Juskiewicz Zuzanna J, Alexander Simon S, Gaultier Alban, Abbott Stephen B G, Shin Jung-Bum, Isakson Brant E, Xu Wehao, Leitinger Norbert, Santos Webster L, Lynch Kevin R

Diverse actions of 15 structurally unrelated mitochondrial uncouplers in cells and mice

15种结构不相关的线粒体解偶联剂在细胞和小鼠中的不同作用

Shah, Divya P; Vancuylenburg, Calum S; Olzomer, Ellen M; Chen, Sing-Young; Grams, Robert J; Beretta, Martina; Byrne, Frances L; Santos, Webster L; Hoehn, Kyle L

Structure-activity relationship study of benserazide derivatives as PilB inhibitors

苄丝肼衍生物作为PilB抑制剂的构效关系研究

Quinlan, Joseph E; Soleymani, Ghazal; Shimozono, Tori M; Yang, Zhaomin; Santos, Webster L

Unsymmetric hydroxylamine and hydrazine BAM15 derivatives as potent mitochondrial uncouplers.

不对称羟胺和肼 BAM15 衍生物作为有效的线粒体解偶联剂

Quinlan Joseph E, Salamoun Joseph M, Garcia Christopher J, Hargett Stefan, Beretta Martina, Shrestha Riya, Li Catherine, Hoehn Kyle L, Santos Webster L

Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice

肝脏选择性咪唑并吡嗪类线粒体解偶联剂SHD865可逆转小鼠的肥胖和葡萄糖耐受不良

Beretta, Martina; Dai, Yumin; Olzomer, Ellen M; Vancuylenburg, Calum S; Santiago-Rivera, José A; Philp, Ashleigh M; Hargett, Stefan R; Li, Keyong; Shah, Divya P; Chen, Sing-Young; Alexopoulos, Stephanie J; Li, Catherine; Harris, Thurl E; Lee, Brendan; Wathier, Michel; Cermak, Jennifer M; Tucker, Simon P; Turner, Nigel; Bayliss, Douglas A; Philp, Andrew; Byrne, Frances L; Santos, Webster L; Hoehn, Kyle L

Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors

发现高效、口服生物利用度高的鞘氨醇-1-磷酸转运蛋白(Spns2)抑制剂

Foster, Daniel J; Dunnavant, Kyle; Shrader, Christopher W; LoPresti, Marion; Seay, Sarah; Kharel, Yugesh; Brown, Anne M; Huang, Tao; Lynch, Kevin R; Santos, Webster L

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis.

[1,2,5]恶二唑并[3,4-b]吡啶-7-醇作为线粒体解偶联剂治疗肥胖和代谢功能障碍相关脂肪性肝炎的设计、合成和生物学评价

Foutz Mary A, Krinos Emily L, Beretta Martina, Hargett Stefan R, Shrestha Riya, Murray Jacob H, Duerre Ethan, Salamoun Joseph M, McCarter Katrina, Shah Divya P, Hoehn Kyle L, Santos Webster L

Design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH).

设计、合成和生物学评价咪唑并[4,5-b]吡啶线粒体解偶联剂治疗代谢功能障碍相关脂肪性肝炎(MASH)

Salamoun Joseph M, Krinos Emily L, Foutz Mary A, Hargett Stefan R, Beretta Martina, Shrestha Riya, Hoehn Kyle L, Santos Webster L