日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A programmable ribozyme for RNA signal transduction.

一种用于RNA信号转导的可编程核酶。

Lim Mandy Yu Theng, Tan Chermaine, Subhramanyam Charannya Sozheesvari, Teo Shi Jie, DeFalco Louis, Pasaribu Samuel Kevin, Koh Chong Hui, Rayamajhi Dheeraj, Chi Jieying, Li Shengnan, Wee Keng Boon, Roy Sudipto, Huber Roland G, Aw Sherry Shiying

BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypes.

通过剪接转换寡核苷酸耗竭 BLOC1S1 可改善线粒体呼吸并挽救 ALS 表型。

Hor Jin-Hui, Ow Jin Rong, Ng Winanto, Ramasamy Boominathan, Tabaglio Tommaso, Lim Kimberly Ngee Hui, Bin Muzakar Muhammad Ikhsan, Lim Valerie Jing Wen, Gurrampati Rajasekhar Reddy, Rajarethinam Ravisankar, Ngo Shyuan T, Ramadass Venkataramanan, Ling Shuo-Chien, Lakshmanan Manikandan, Wee Keng Boon, Ng Shi-Yan

Utargetome: A targetome prediction tool for modified U1-snRNAs to identify distal-target positions with improved selectivity

Utargetome:一种针对修饰的U1-snRNA的靶标组预测工具,可识别具有更高选择性的远端靶标位置

Pigini, Paolo; Giorgi, Federico Manuel; Wee, Keng Boon

SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements.

SRSF3 通过调节可变剪接和转座元件来维持卵母细胞中转录组的完整性

Do Dang Vinh, Strauss Bernhard, Cukuroglu Engin, Macaulay Iain, Wee Keng Boon, Hu Tim Xiaoming, Igor Ruiz De Los Mozos, Lee Caroline, Harrison Andrew, Butler Richard, Dietmann Sabine, Jernej Ule, Marioni John, Smith Christopher W J, Göke Jonathan, Surani M Azim

Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance

发现甲型流感病毒序列对及其组合,可同时靶向多种异亚型,从而抵御抗病毒药物耐药性。

Wee, Keng Boon; Lee, Raphael Tze Chuen; Lin, Jing; Pramono, Zacharias Aloysius Dwi; Maurer-Stroh, Sebastian

Dual masking of specific negative splicing regulatory elements resulted in maximal exon 7 inclusion of SMN2 gene

双重掩蔽特定的负剪接调控元件导致SMN2基因的第7外显子最大程度地插入。

Pao, Peng Wen; Wee, Keng Boon; Yee, Woon Chee; Pramono, Zacharias Aloysius Dwi

A prospective study in the rational design of efficient antisense oligonucleotides for exon skipping in the DMD gene

一项关于合理设计高效反义寡核苷酸以进行DMD基因外显子跳跃的前瞻性研究

Pramono, Zacharias Aloysius Dwi; Wee, Keng Boon; Wang, Jian Li; Chen, Yi Jun; Xiong, Qian Bin; Lai, Poh San; Yee, Woon Chee

Transcription factor oscillations induce differential gene expressions

转录因子振荡诱导差异基因表达

Wee, Keng Boon; Yio, Wee Kheng; Surana, Uttam; Chiam, Keng Hwee

Oscillations of the p53-Akt network: implications on cell survival and death

p53-Akt网络振荡:对细胞存活和死亡的影响

Wee, Keng Boon; Surana, Uttam; Aguda, Baltazar D

Dynamics of co-transcriptional pre-mRNA folding influences the induction of dystrophin exon skipping by antisense oligonucleotides

共转录前体mRNA折叠的动态变化影响反义寡核苷酸诱导的肌营养不良蛋白外显子跳跃

Wee, Keng Boon; Pramono, Zacharias Aloysius Dwi; Wang, Jian Li; MacDorman, Karl F; Lai, Poh San; Yee, Woon Chee