Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1
杂合 PSEN1 突变产生致病性 Aβ 是突变蛋白的内在特性,而非由野生型 PSEN1 的构象障碍介导
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1016/j.jbc.2023.104997
Vanessa Kurth, Isabella Ogorek, Carolina Münch, Javier Lopez-Rios, Solenne Ousson, Sandra Lehmann, Katja Nieweg, Anton J M Roebroek, Claus U Pietrzik, Dirk Beher, Sascha Weggen