日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Engineered LINC MIR503HG-loaded extracellular vesicles maintain stemness and pluripotency during long-term hiPSCs culture.

工程化的 LINC MIR503HG 负载细胞外囊泡在长期 hiPSCs 培养过程中维持干性和多能性。

期刊:Bioactive Materials
影响因子:20.3
doi:10.1016/j.bioactmat.2025.12.023
Zhu Jiaqi, Zhu Xiaoren, Feng Wei, Jin Yi, Ge Xinqi, Li Yuxi, Xue Xiaoxia, Wang Zhiwei, Xu Yang, Huang Yan
囊泡
细胞生物学
发表日期：2026
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Tomato antiviral ubiquitin-proteasome system recognizes viral 59 kDa protein to confer tomato chlorosis virus resistance.

番茄抗病毒泛素-蛋白酶体系统识别病毒 59kDa 蛋白，从而赋予番茄抗褪绿病毒的能力。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-68832-3
Zhao Dan, Liu Xiaoqian, Li Hongbo, Xia Tianchen, Jia Qi, Li Peidong, Shan Qing, Li Changqian, Li Hui, Gai Yilei, Lin Tao, Zang Lianyi, Zhou Tao, Wei Jin-Wei, Zhu Xiaoping, Gong Biao
微生物学
发表日期：2026
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Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

USP7 和 RNF40 的拮抗性泛素转换调控 KDM6A 稳态，从而导致冠状病毒易感性

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202518058
Huang, Meng-Zhuo; Yang, Zhong-Yuan; Wang, Shi; Ge, Yan; Lin, Lan; Alfajaro, Mia Madel; Filler, Renata B; Song, Wan-Yao; Kong, Ming-Zhu; Wei, Jin
微生物学
信号转导
SP7
KDM6A
发表日期：2026
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Engineering CLL-1 CAR-NK cells via mRNA-LNP for potent antitumor activity and reversal of HLA-E-mediated resistance in acute myeloid leukemia

利用 mRNA-LNP 对 CLL-1 CAR-NK 细胞进行工程改造，以增强其抗肿瘤活性并逆转急性髓系白血病中 HLA-E 介导的耐药性。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03689-4
Shen, Jie; Jin, Peng; Liang, Yebing; Zhu, Jinyang; Xiang, Rufang; Li, Zeyi; Zhu, Hongming; Li, Xiaoyang; Zhang, Yunxiang; Wang, Wei; Jin, Zhen; Li, Junmin
NK 细胞
白血病
肿瘤
细胞生物学
肿瘤免疫
CAR-NK
发表日期：2026
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KNUCKLES promotes meiotic cell-cycle progression by directly repressing the expression of KRP1 and KRP3 to ensure male fertility

KNUCKLES通过直接抑制KRP1和KRP3的表达来促进减数分裂细胞周期进程，从而确保雄性生育能力。

期刊:Plant Communications
影响因子:11.6
doi:10.1016/j.xplc.2025.101610
Chang, Yongsheng; Chen, Zhiyu; Chen, Wei; Jin, Xueying; Wang, Xin; Zhan, Huadong; Cao, Ling; Wang, Hong; Wang, Yingxiang; Wang, Cong; Sun, Bo
细胞生物学
发表日期：2026
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Anti-TIM-3 antibody TQB2618 in combination with penpulimab in relapsed or refractory classic Hodgkin lymphoma previously treated with PD-1/PD-L1 therapy: a multicenter, open-label, single-arm, phase Ib clinical trial

抗TIM-3抗体TQB2618联合penpulimab治疗既往接受过PD-1/PD-L1靶向治疗的复发或难治性经典霍奇金淋巴瘤：一项多中心、开放标签、单臂Ib期临床试验

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2026-014968
Hong, Huangming; Chen, Zegeng; Cui, Jie; Zhang, Qingyuan; Li, Ping; Tao, Rong; Huang, He; Wang, Binghua; Li, Wuping; Wu, Hui; Wei, Jin; Su, Liping; Zhang, Zhihua; Zhong, Mingxing; Wang, Huaqing; Wang, Cong; Zhou, Hui; Wang, Jishi; Dong, Min; Lin, Tongyu
PD-L1
淋巴瘤
TIM
PD-1
发表日期：2026
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PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma

PTPN22 通过使 CBL 去磷酸化来抑制 PD-L1 泛素化，从而在肾细胞癌中驱动免疫抑制。

期刊:International Journal of Biological Sciences
影响因子:10
doi:10.7150/ijbs.122418
Jin, Taian; Ma, Jiahui; Wang, Luping; Liu, Xinbo; Wu, Mengting; Wang, Binqi; Gao, Chan; Zhu, Siqi; Zhang, Ruikai; Xia, Fanwei; Tian, Jingkui; Zhu, Wei; Jin, Juan; He, Qiang
肿瘤
表观遗传
肿瘤免疫
信号转导
泛素化
肾癌
PD-L1
磷酸化
细胞生物学
免疫/内分泌
发表日期：2026
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FKBP10 promotes M2 polarization of macrophage via MEK/ERK/CXCL8 axis and facilitates tumor progression in clear cell renal cell carcinoma

FKBP10 通过 MEK/ERK/CXCL8 轴促进巨噬细胞 M2 极化，并促进透明细胞肾细胞癌的肿瘤进展。

期刊:International Journal of Biological Sciences
影响因子:10
doi:10.7150/ijbs.117535
Chen, Jin-Wei; Li, Jia-Ying; Feng, Hao-Qian; Fu, Liang-Min; Zhou, Xin-Wei; Lin, Han-Sen; Wang, Ying-Han; Liu, Ke-Zhi; Chen, Yu-Hang; Wang, Zhu; Deng, Qiong; Wang, Jie-Yan; Jin, Mei-Yu; Liang, Hui; Wei, Jin-Huan; Luo, Jun-Hang; Gui, Cheng-Peng
巨噬细胞
肿瘤
肿瘤免疫
巨噬细胞
肾癌
MAPK/ERK
细胞生物学
CXCL8
免疫/内分泌
发表日期：2026
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The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury

m5C 调控因子 NSUN7 驱动 SPARC/HMGB1 轴介导的炎症反应，从而加剧肾损伤。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2511296123
Dong, Yu-Hang; Xie, Shuai-Shuai; Sun, Shuai; Ren, Yu; Yang, Qin; Wei, Jie; Hou, Rui; Li, Xiang-Yu; Wu, Jing-Wen; Ma, Wen-Xian; Yu, Ju-Tao; He, Meng-Ting; Li, Chao; Wang, Jia-Nan; Ji, Ming-Lu; Liu, Zi-Yi; Dong, Ze-Hui; Shen, Xiao-Yu; Chen, Xin-Yu; Suo, Xiao-Guo; Dong, Wei; Jin, Juan; Wang, Jie; Wang, Wen-Bin; Meng, Xiao-Ming
m6A/m5C/m7G
炎症
炎症/感染
信号转导
肾损伤
HMGB1
ARC
毒理研究
发表日期：2026
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Role of Preoptic Area γ-Aminobutyric Acid-mediated Neurons in Distinctly Regulating Sleep and Rousability during Dexmedetomidine Sedation in Mice.

视前区α-氨基丁酸介导神经元在右美托咪定镇静小鼠中独特地调节睡眠和觉醒的作用。

期刊:Anesthesiology
影响因子:9.1
doi:10.1097/ALN.0000000000005953
Qiu Gaolin, Wang Peng, Yang Zhilai, Qing Xin, Wang Dijia, Gao Beijia, Zhang Jiqian, Zhang Huiwen, Liu Hu, Mei Bin, Dai Wei, Jin Li, Wang Jiansheng, Zhu Qianyun, Rao Jin, Liu Xuesheng
神经科学
发表日期：2026
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