Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation.
HRMEC 中的乳酸结合蛋白 DNMT3A 通过 HIF-1α 乳酸化上调 VEGFA 来促进血管生成。
期刊:Genome Biology
影响因子:9.4
doi:10.1186/s13059-025-03845-7
Wang Xiaotang, Huang Jiaxing, Fan Wei, Li Na, Yang Hui, Yang Wenxian, Li Wanqian, Li Ruonan, Liu Jiangyi, Li Xingran, Zhou Qian, Hou Shengping
心血管
EGF
VEGF
VEGFA
DNMT3A
Angiogenesis
乳酸化
血管生成