MDM2 drives resistance to Osimertinib by contextually disrupting FBW7-mediated destruction of MCL-1 protein in EGFR mutant NSCLC
MDM2通过在EGFR突变型非小细胞肺癌中干扰FBW7介导的MCL-1蛋白降解,从而驱动对奥希替尼的耐药性。
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-024-03220-7
Liu, Jiaxin; Wei, Lingyun; Miao, Qing; Zhan, Sutong; Chen, Peilin; Liu, Wei; Cao, Liang; Wang, Dong; Liu, Hongbing; Yin, Jie; Song, Yong; Ye, Mingxiang; Lv, Tangfeng
肺癌
肿瘤
肿瘤免疫
MDM2
EGF
蛋白降解
EGFR
细胞生物学