TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis.
TRIM25 通过泛素蛋白酶体途径降低 BRD7 蛋白的稳定性，通过激活 YB1/Bcl-2 转录轴促进乳腺癌进展和紫杉醇耐药性。
期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08140-8
Xue Changning, Wei Qingqing, Li Mengna, Wei Jianxia, Zheng Lemei, Wu Zubing, Xin Huizhen, Duan Yumei, Fan Songqing, Xiong Wei, Li Guiyuan, Tang Faqing, Deng Hongyu, Zhou Ming
