日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts

一种基于FAPI的小分子药物偶联物通过靶向表达致病性FAPα的成纤维细胞来缓解类风湿性关节炎。

期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-025-01680-x
Qian, Hong-Yan; He, Yan; Deng, Chao-Qiong; Wang, Ao-di; Ma, Yong-Xin; Zhuang, Hong-Jun; Chen, Shi-Peng; Li, Yan; Chen, Shi-Ju; Zhang, Xin-Wei; Jan, Nasrullah; Shi, Gui-Xiu; Liu, Yuan
成纤维细胞
关节炎
FAP
细胞生物学
发表日期：2026
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CCAAT/enhancer-binding protein delta regulates miRs-4257 and 3156 to attenuate the interleukin 12 through small extracellular vesicle transmission in glioblastoma

CCAAT/增强子结合蛋白δ通过调节miR-4257和3156，经由胶质母细胞瘤中小细胞外囊泡的传递减弱白细胞介素12的表达。

期刊:Cancer Cell International
影响因子:6
doi:10.1186/s12935-026-04225-2
Chu, Yu-Yi; Ko, Chiung-Yuan; Wang, Shao-Ming; Wang, Wei-Jan; Wang, Chih-Yang; Chen, Feng-Wei; Liang, Hsin-Yin; Wang, Ju-Ming
囊泡
细胞生物学
发表日期：2026
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AMIGO2 as a Novel Biomarker Predicting Poor Prognosis and Associated with Adhesion-Driven Metastasis in Pancreatic Adenocarcinoma

AMIGO2作为一种新型生物标志物，可预测胰腺腺癌预后不良并与黏附驱动的转移相关

期刊:International Journal of Medical Sciences
影响因子:3.2
doi:10.7150/ijms.121794
Chen, Ze-Syuan; Chang, Tsung-Shun; Shen, Wan-Jou; Liu, Shan-Ju; Wang, Chih-Yang; Lee, Yung-Kuo; Hsu, Wen-Hsin; Wang, Wei-Jan
肿瘤
MIG
肿瘤免疫
发表日期：2026
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Young People's Satisfaction With and Perceived Impact of a Multichannel Mental Health Helpline During and After COVID-19 Pandemic: Mixed Methods Analysis of Cross-Sectional Survey Data

新冠疫情期间及之后，年轻人对多渠道心理健康热线的满意度和感知影响：基于横断面调查数据的混合方法分析

期刊:JMIR Formative Research
影响因子:
doi:10.2196/68507
Phua, Shyn Wei; Jan, Anya; Zheng, Guanlin; Gutman, Leslie Morrison
微生物学
新冠
发表日期：2026
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The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo

细胞周期蛋白依赖性激酶8抑制剂E966-0530-45418在体外和体内均能减轻肺纤维化

期刊:International Journal of Biological Sciences
影响因子:8.2
doi:10.7150/ijbs.105826
Ching-Hsuan Chou,Wei-Jan Huang,Kai-Cheng Hsu,Jui-Yi Hsu,Tony Eight Lin,Chia-Ron Yang
细胞生物学
发表日期：2025
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CircRNA hsa_circ_0004781 promoted cell proliferation by acting as a sponge for miR-9-5p and miR-338-3p and upregulating KLF5 and ADAM17 expression in pancreatic ductal adenocarcinoma

环状RNA hsa_circ_0004781通过作为miR-9-5p和miR-338-3p的分子海绵，并上调KLF5和ADAM17的表达，促进胰腺导管腺癌细胞增殖。

期刊:Cancer Cell International
影响因子:6
doi:10.1186/s12935-025-03687-0
Lee, Kun-Lin; Liu, Jun-Jen; Huang, Wei-Jan; Hung, Ching-Sheng; Liang, Yu-Chih
ADAM17
肿瘤
肿瘤免疫
细胞生物学
KLF5
ADA
发表日期：2025
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Exploring diarylheptanoid derivatives to target LIMK1 as potential agents against colorectal cancer

探索以LIMK1为靶点的二芳基庚烷衍生物作为潜在的结直肠癌治疗药物

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2583826
Chen, Liang-Chieh; Chang, Tung-Cheng; Tseng, Hui-Ju; Chu, Jung-Chun; Huang, Yun-Yi; Peng, Hao-Yuan; Kuo, Yi-Chen; Wu, Yi-Wen; Lin, Tony Eight; Yen, Shih-Chung; Hsu, Kai-Cheng; Huang, Wei-Jan; Pan, Shiow-Lin
肿瘤
肠癌
肿瘤免疫
LIMK1
发表日期：2025
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Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening

利用基于结构的虚拟筛选鉴定高效 CDK8 抑制剂

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.4c02011
Lin, Tony Eight; Chou, Ching-Hsuan; Wu, Yi-Wen; Sung, Tzu-Ying; Hsu, Jui-Yi; Yen, Shih-Chung; Hsieh, Jui-Hua; Chang, Yu-Wei; Pan, Shiow-Lin; Huang, Wei-Jan; Hsu, Kai-Cheng; Yang, Chia-Ron
CDK8
发表日期：2025
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The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin

基于羟肟酸酯的HDAC抑制剂WMJ-J-09通过靶向微管蛋白并下调survivin诱导结直肠癌细胞死亡。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-04714-w
Huang, Yu-Han; Huang, Yu-Min; Huang, Wei-Jan; Yu, Meng-Chieh; Chuang, Chin-Hui; Hsu, Ya-Fen; Chen, Hsiu-Chen; Chen, Liang-Chieh; Huang, Shiu-Wen; Hsu, Ming-Jen
细胞生物学
肿瘤
肠癌
肿瘤免疫
发表日期：2025
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Tumor-derived lactate fuels the STAT3-LCN2 pathway to promote bladder cancer malignancy and chemoresistance.

肿瘤来源的乳酸为 STAT3-LCN2 通路提供能量，从而促进膀胱癌的恶性进展和化疗耐药性。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-25534-y
Yu Shih-Yu, Li Hao-Yi, Wang Chi-Yun, Wang Wei-Jan, Hsu Shih-Hao, Hsiang Min-Chen, Yee Ke-Xin, Lee Kuen-Haur, Lee Yu-Cheng
膀胱癌
信号转导
TAT
LCN2
STAT3
发表日期：2025
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