日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling

固有无序结构域在调节G蛋白偶联受体信号传导中的作用

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c17796
Xu, Jun; Qiu, Ruoyi; Garces, Alexander M; Hübner, Harald; Xu, Xinyu; Hao, Chengyu; Weikert, Dorothee; Gmeiner, Peter; Lerch, Michael T; Kobilka, Brian K
信号转导
发表日期：2026
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Mechanism and function of GPR3 regulated by a negative allosteric modulator.

负变构调节剂调控 GPR3 的机制和功能

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-63422-1
Chen Geng, Bláhová Jana, Staffen Nico, Hübner Harald, Nunhöfer Nadja, Qiu Chen, Gmeiner Peter, Weikert Dorothee, Du Yang, Xu Jun
其它
发表日期：2025
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Discovery of a functionally selective serotonin receptor (5-HT(1A)R) agonist for the treatment of pain.

发现一种功能选择性血清素受体（5-HT(1A)R）激动剂用于治疗疼痛

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adv9267
Ullrich Annika, Schneider Johannes, Braz João M, Neu Eduard, Staffen Nico, Stanek Markus, Bláhová Jana, Hove Tamsanqa, Albert Tamara, Allikalt Anni, Löber Stefan, Bhardwaj Karnika, Rodriguez-Rosado Sian, Fink Elissa, Rasmussen Tim, Hübner Harald, Inoue Asuka, Shoichet Brian K, Basbaum Allan I, Böttcher Bettina, Weikert Dorothee, Gmeiner Peter
其它
发表日期：2025
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The role of intrinsically disordered domains in regulating G protein coupled receptor signaling

固有无序结构域在调节G蛋白偶联受体信号传导中的作用

期刊:
影响因子:
doi:10.1101/2025.09.10.675278
Xu, Jun; Qiu, Ruoyi; Garces, Alexander M; Hübner, Harald; Xu, Xinyu; Weikert, Dorothee; Gmeiner, Peter; Lerch, Michael T; Kobilka, Brian K
信号转导
发表日期：2025
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Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

内体中神经激肽1受体的治疗性拮抗作用可提供持续的镇痛效果

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2220979120
Hegron, Alan; Peach, Chloe J; Tonello, Raquel; Seemann, Philipp; Teng, Shavonne; Latorre, Rocco; Huebner, Harald; Weikert, Dorothee; Rientjes, Jeanette; Veldhuis, Nicholas A; Poole, Daniel P; Jensen, Dane D; Thomsen, Alex R B; Schmidt, Brian L; Imlach, Wendy L; Gmeiner, Peter; Bunnett, Nigel W
信号转导
发表日期：2023
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Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands

抑制一种具有广泛结合能力的GPCR：苦味受体配体的迭代发现

期刊:Cellular and Molecular Life Sciences
影响因子:6.2
doi:10.1007/s00018-023-04765-0
Fierro, Fabrizio; Peri, Lior; Hübner, Harald; Tabor-Schkade, Alina; Waterloo, Lukas; Löber, Stefan; Pfeiffer, Tara; Weikert, Dorothee; Dingjan, Tamir; Margulis, Eitan; Gmeiner, Peter; Niv, Masha Y
信号转导
GPCR/Calcium/cAMP
发表日期：2023
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Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs

用于研究GPCR细胞内变构结合位点细胞靶点结合的小分子工具

期刊:Chemistry-A European Journal
影响因子:3.7
doi:10.1002/chem.202202565
Huber, Max E; Toy, Lara; Schmidt, Maximilian F; Weikert, Dorothee; Schiedel, Matthias
细胞生物学
GPCR/Calcium/cAMP
发表日期：2023
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A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs

针对CCR9细胞内结合位点的化学生物学工具箱：荧光配体、新药先导化合物和PROTACs

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202116782
Huber, Max E; Toy, Lara; Schmidt, Maximilian F; Vogt, Hannah; Budzinski, Julian; Wiefhoff, Martin F J; Merten, Nicole; Kostenis, Evi; Weikert, Dorothee; Schiedel, Matthias
细胞生物学
IF
发表日期：2022
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Structure-based development of a subtype-selective orexin 1 receptor antagonist

基于结构的亚型选择性食欲素1受体拮抗剂的开发

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2002704117
Hellmann, Jan; Drabek, Matthäus; Yin, Jie; Gunera, Jakub; Pröll, Theresa; Kraus, Frank; Langmead, Christopher J; Hübner, Harald; Weikert, Dorothee; Kolb, Peter; Rosenbaum, Daniel M; Gmeiner, Peter
信号转导
发表日期：2020
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Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back

苦味受体TAS2R14激动剂的合理设计：从模型构建到实验验证再到回归分析

期刊:Cellular and Molecular Life Sciences
影响因子:6.2
doi:10.1007/s00018-019-03194-2
Di Pizio, Antonella; Waterloo, Lukas A W; Brox, Regine; Löber, Stefan; Weikert, Dorothee; Behrens, Maik; Gmeiner, Peter; Niv, Masha Y
信号转导
发表日期：2020
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