日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic potential of allosteric HECT E3 ligase inhibition.

变构 HECT E3 连接酶抑制的治疗潜力

Rothman Alexander M K, Florentin Amir, Zink Florence, Quigley Catherine, Bonneau Olivier, Hemmig Rene, Hachey Amanda, Rejtar Tomas, Thaker Maulik, Jain Rishi, Huang Shih-Min, Sutton Daniel, Roger Jan, Zhang Ji-Hu, Weiler Sven, Cotesta Simona, Ottl Johannes, Srivastava Salil, Kordonsky Alina, Avishid Reut, Yariv Elon, Rathi Ritu, Khvalevsky Oshrit, Troxler Thomas, Binmahfooz Sarah K, Kleifeld Oded, Morrell Nicholas W, Humbert Marc, Thomas Matthew J, Jarai Gabor, Beckwith Rohan E J, Cobb Jennifer S, Smith Nichola, Ostermann Nils, Tallarico John, Shaw Duncan, Guth-Gundel Sabine, Prag Gali, Rowlands David J

Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase‑2 (ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva

Zilurgisertib 的发现和表征:一种强效且选择性的激活素受体样激酶-2 (ALK2) 抑制剂,用于治疗进行性骨化性纤维发育不良症

Ullrich, Thomas; Guth, Sabine; Arista, Luca; Weiler, Sven; Stiefl, Nikolaus; Teixeira-Fouchard, Sylvie; Dekker, Carien; Hinniger, Alexandra; Head, Victoria; Kneissel, Michaela; Kramer, Ina