日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comprehensive genomic dependency landscape of a human colon cancer organoid.

人类结肠癌类器官的全面基因组依赖性图谱

Khalili Sana, Mohseninia Atefeh, Liu Changlong, Banister Carolyn E, Heine Paige, Khazan Minou, Morrison Sidney E, Gokare Prashanth, Cowley Glenn S, Weir Barbara A, Pocalyko David, Bachman Kurtis E, Buckhaults Phillip J

Next-generation characterization of the Cancer Cell Line Encyclopedia

下一代癌症细胞系百科全书的表征

Ghandi, Mahmoud; Huang, Franklin W; Jané-Valbuena, Judit; Kryukov, Gregory V; Lo, Christopher C; McDonald, E Robert 3rd; Barretina, Jordi; Gelfand, Ellen T; Bielski, Craig M; Li, Haoxin; Hu, Kevin; Andreev-Drakhlin, Alexander Y; Kim, Jaegil; Hess, Julian M; Haas, Brian J; Aguet, François; Weir, Barbara A; Rothberg, Michael V; Paolella, Brenton R; Lawrence, Michael S; Akbani, Rehan; Lu, Yiling; Tiv, Hong L; Gokhale, Prafulla C; de Weck, Antoine; Mansour, Ali Amin; Oh, Coyin; Shih, Juliann; Hadi, Kevin; Rosen, Yanay; Bistline, Jonathan; Venkatesan, Kavitha; Reddy, Anupama; Sonkin, Dmitriy; Liu, Manway; Lehar, Joseph; Korn, Joshua M; Porter, Dale A; Jones, Michael D; Golji, Javad; Caponigro, Giordano; Taylor, Jordan E; Dunning, Caitlin M; Creech, Amanda L; Warren, Allison C; McFarland, James M; Zamanighomi, Mahdi; Kauffmann, Audrey; Stransky, Nicolas; Imielinski, Marcin; Maruvka, Yosef E; Cherniack, Andrew D; Tsherniak, Aviad; Vazquez, Francisca; Jaffe, Jacob D; Lane, Andrew A; Weinstock, David M; Johannessen, Cory M; Morrissey, Michael P; Stegmeier, Frank; Schlegel, Robert; Hahn, William C; Getz, Gad; Mills, Gordon B; Boehm, Jesse S; Golub, Todd R; Garraway, Levi A; Sellers, William R

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

MTAP缺失导致癌细胞对PRMT5精氨酸甲基转移酶的依赖性增强。

Kryukov, Gregory V; Wilson, Frederick H; Ruth, Jason R; Paulk, Joshiawa; Tsherniak, Aviad; Marlow, Sara E; Vazquez, Francisca; Weir, Barbara A; Fitzgerald, Mark E; Tanaka, Minoru; Bielski, Craig M; Scott, Justin M; Dennis, Courtney; Cowley, Glenn S; Boehm, Jesse S; Root, David E; Golub, Todd R; Clish, Clary B; Bradner, James E; Hahn, William C; Garraway, Levi A

Characterizing genomic alterations in cancer by complementary functional associations

通过互补功能关联来表征癌症中的基因组改变

Kim, Jong Wook; Botvinnik, Olga B; Abudayyeh, Omar; Birger, Chet; Rosenbluh, Joseph; Shrestha, Yashaswi; Abazeed, Mohamed E; Hammerman, Peter S; DiCara, Daniel; Konieczkowski, David J; Johannessen, Cory M; Liberzon, Arthur; Alizad-Rahvar, Amir Reza; Alexe, Gabriela; Aguirre, Andrew; Ghandi, Mahmoud; Greulich, Heidi; Vazquez, Francisca; Weir, Barbara A; Van Allen, Eliezer M; Tsherniak, Aviad; Shao, Diane D; Zack, Travis I; Noble, Michael; Getz, Gad; Beroukhim, Rameen; Garraway, Levi A; Ardakani, Masoud; Romualdi, Chiara; Sales, Gabriele; Barbie, David A; Boehm, Jesse S; Hahn, William C; Mesirov, Jill P; Tamayo, Pablo

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.

利用条形码标记的肿瘤细胞系混合物进行高通量基因型特异性癌症脆弱性鉴定

Yu Channing, Mannan Aristotle M, Yvone Griselda Metta, Ross Kenneth N, Zhang Yan-Ling, Marton Melissa A, Taylor Bradley R, Crenshaw Andrew, Gould Joshua Z, Tamayo Pablo, Weir Barbara A, Tsherniak Aviad, Wong Bang, Garraway Levi A, Shamji Alykhan F, Palmer Michelle A, Foley Michael A, Winckler Wendy, Schreiber Stuart L, Kung Andrew L, Golub Todd R

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

通过对扩增基因进行体内多重检测,鉴定出 GAB2 为卵巢癌癌基因。

Dunn, Gavin P; Cheung, Hiu Wing; Agarwalla, Pankaj K; Thomas, Sapana; Zektser, Yulia; Karst, Alison M; Boehm, Jesse S; Weir, Barbara A; Berlin, Aaron M; Zou, Lihua; Getz, Gad; Liu, Joyce F; Hirsch, Michelle; Vazquez, Francisca; Root, David E; Beroukhim, Rameen; Drapkin, Ronny; Hahn, William C

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

在216个癌细胞系中进行平行全基因组规模的功能缺失筛选,以识别特定背景下的遗传依赖性

Cowley, Glenn S; Weir, Barbara A; Vazquez, Francisca; Tamayo, Pablo; Scott, Justine A; Rusin, Scott; East-Seletsky, Alexandra; Ali, Levi D; Gerath, William Fj; Pantel, Sarah E; Lizotte, Patrick H; Jiang, Guozhi; Hsiao, Jessica; Tsherniak, Aviad; Dwinell, Elizabeth; Aoyama, Simon; Okamoto, Michael; Harrington, William; Gelfand, Ellen; Green, Thomas M; Tomko, Mark J; Gopal, Shuba; Wong, Terence C; Li, Hubo; Howell, Sara; Stransky, Nicolas; Liefeld, Ted; Jang, Dongkeun; Bistline, Jonathan; Hill Meyers, Barbara; Armstrong, Scott A; Anderson, Ken C; Stegmaier, Kimberly; Reich, Michael; Pellman, David; Boehm, Jesse S; Mesirov, Jill P; Golub, Todd R; Root, David E; Hahn, William C

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

β-catenin驱动的癌症需要YAP1转录复合物才能存活和发生肿瘤。

Rosenbluh, Joseph; Nijhawan, Deepak; Cox, Andrew G; Li, Xingnan; Neal, James T; Schafer, Eric J; Zack, Travis I; Wang, Xiaoxing; Tsherniak, Aviad; Schinzel, Anna C; Shao, Diane D; Schumacher, Steven E; Weir, Barbara A; Vazquez, Francisca; Cowley, Glenn S; Root, David E; Mesirov, Jill P; Beroukhim, Rameen; Kuo, Calvin J; Goessling, Wolfram; Hahn, William C

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

靶向肿瘤穿透性siRNA纳米复合物用于鉴定卵巢癌癌基因ID4

Ren, Yin; Cheung, Hiu Wing; von Maltzhan, Geoffrey; Agrawal, Amit; Cowley, Glenn S; Weir, Barbara A; Boehm, Jesse S; Tamayo, Pablo; Karst, Alison M; Liu, Joyce F; Hirsch, Michelle S; Mesirov, Jill P; Drapkin, Ronny; Root, David E; Lo, Justin; Fogal, Valentina; Ruoslahti, Erkki; Hahn, William C; Bhatia, Sangeeta N

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

对癌细胞系遗传脆弱性的系统性研究揭示了卵巢癌中谱系特异性依赖性

Cheung, Hiu Wing; Cowley, Glenn S; Weir, Barbara A; Boehm, Jesse S; Rusin, Scott; Scott, Justine A; East, Alexandra; Ali, Levi D; Lizotte, Patrick H; Wong, Terence C; Jiang, Guozhi; Hsiao, Jessica; Mermel, Craig H; Getz, Gad; Barretina, Jordi; Gopal, Shuba; Tamayo, Pablo; Gould, Joshua; Tsherniak, Aviad; Stransky, Nicolas; Luo, Biao; Ren, Yin; Drapkin, Ronny; Bhatia, Sangeeta N; Mesirov, Jill P; Garraway, Levi A; Meyerson, Matthew; Lander, Eric S; Root, David E; Hahn, William C