日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proximity-Induced Rewiring of Oncogenic Kinase Triggers Apoptosis

邻近诱导的致癌激酶重编程触发细胞凋亡

Merz, Manuel L; Shoba, Veronika M; Pergu, Rajaiah; Severance, Zachary C; Munkanatta Godage, Dhanushka N P; Deb, Arghya; Kwok, Hui Si; Singh, Prashant; Singh, Sameek; Allen, Jonathan B; Tian, Wenzhi; Gosavi, Pallavi M; Chaudhary, Santosh K; Anokhina, Viktoriya; Weisberg, Ellen L; Payne, N Connor; He, Yao; Dhaliwal, Rohil; Osadchey, Reilly; Shekhar, Mrinal; Mazitschek, Ralph; Rees, Matthew G; Roth, Jennifer A; Cui, Qiang; Griffin, James D; Liau, Brian B; Choudhary, Amit

Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain

利用与假激酶结构域结合的赖氨酸反应性化合物对JAK2进行变构抑制

Primi, Marina C; Tavares, Maurício T; Hatcher, John M; Kang, Hyelim; Kresina, Tomás A C; Chakraborty, Sayan; Leroy, Emilie; Schmoker, Anna M; Jeon, Hyesung; Weisberg, Ellen L; Akatsu, Taisei; Griffin, James D; Scott, David A; Eck, Michael J

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis.

磷酸化诱导嵌合体重塑致癌激酶以触发细胞凋亡

Merz Manuel L, Shoba Veronika M, Pergu Rajaiah, Severance Zachary C, Munkanatta Godage Dhanushka N P, Deb Arghya, Kwok Hui Si, Singh Prashant, Singh Sameek, Allen Jonathan B, Tian Wenzhi, Gosavi Pallavi M, Chaudhary Santosh K, Anokhina Viktoriya, Weisberg Ellen L, Payne N Connor, He Yao, Osadchey Reilly, Shekhar Mrinal, Mazitschek Ralph, Rees Matthew G, Roth Jennifer A, Cui Qiang, Griffin James D, Liau Brian B, Choudhary Amit

Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

靶向分子伴侣蛋白HSP70作为FLT3-ITD阳性急性髓系白血病的新型治疗策略

Hu, Chen; Zou, Fengming; Wang, Aoli; Miao, Weili; Liang, Qianmao; Weisberg, Ellen L; Wang, Yinsheng; Liu, Jing; Wang, Wenchao; Liu, Qingsong

Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia

一种新型急性髓系白血病抑制剂选择性靶向FLT3-ITD突变体而非FLT3-wt

Wang, Aoli; Hu, Chen; Chen, Cheng; Liang, Xiaofei; Wang, Beilei; Zou, Fengming; Yu, Kailin; Li, Feng; Liu, Qingwang; Qi, Ziping; Wang, Junjie; Wang, Wenliang; Wang, Li; Weisberg, Ellen L; Wang, Wenchao; Li, Lili; Ge, Jian; Xia, Ruixiang; Liu, Jing; Liu, Qingsong

Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM)

STAT3转录因子抑制剂可降低恶性胸膜间皮瘤(MPM)模型中的生长并诱导免疫反应基因表达

Lapidot, Moshe; Case, Abigail E; Larios, Dalia; Gandler, Helen I; Meng, Chengcheng; Tošić, Isidora; Weisberg, Ellen L; Poitras, Michael J; Gokhale, Prafulla C; Paweletz, Cloud P; Podar, Klaus; Salgia, Ravi; Saladi, Srinivas V; Griffin, James D; Frank, David A; Bueno, Raphael; Sattler, Martin

Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition

L-RNA适体(Spiegelmer)、NOX-A12抑制SDF-1诱导的癌基因驱动的髓系白血病细胞迁移,并增强酪氨酸激酶抑制作用

Weisberg, Ellen L; Sattler, Martin; Azab, Abdel Kareem; Eulberg, Dirk; Kruschinski, Anna; Manley, Paul W; Stone, Richard; Griffin, James D

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

髓系白血病细胞中通过糖原合成酶1介导的病理性糖原生成以及对过量AMP激酶活性的抑制

Bhanot, Haymanti; Reddy, Mamatha M; Nonami, Atsushi; Weisberg, Ellen L; Bonal, Dennis; Kirschmeier, Paul T; Salgia, Sabrina; Podar, Klaus; Galinsky, Ilene; Chowdary, Tirumala K; Neuberg, Donna; Tonon, Giovanni; Stone, Richard M; Asara, John; Griffin, James D; Sattler, Martin

Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma

发现一种强效的共价BTK抑制剂,用于治疗B细胞淋巴瘤

Wu, Hong; Wang, Wenchao; Liu, Feiyang; Weisberg, Ellen L; Tian, Bei; Chen, Yongfei; Li, Binhua; Wang, Aoli; Wang, Beilei; Zhao, Zheng; McMillin, Douglas W; Hu, Chen; Li, Hong; Wang, Jinhua; Liang, Yanke; Buhrlage, Sara J; Liang, Junting; Liu, Jing; Yang, Guang; Brown, Jennifer R; Treon, Steven P; Mitsiades, Constantine S; Griffin, James D; Liu, Qingsong; Gray, Nathanael S