日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

利用条形码mRNA进行高通量体内筛选,鉴定出具有肝外趋向性的脂质纳米颗粒,用于原位免疫工程

Hamilton, Alex G; Thatte, Ajay S; Xu, Junchao; Luo, Zhangyi; Safford, Hannah C; Swingle, Kelsey L; Muscat-Rivera, Jenna; Kegel, Michael; Han, Xuexiang; Joseph, Ryann A; Murray, Amanda M; Geisler, Hannah C; Whitaker, Ricardo C; Xue, Lulu; Spektor, Roman; Melamed, Jilian R; Weissman, Drew; Mitchell, Michael J

Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

将DNA-LNP靶向内皮细胞可提高表达强度、持续时间和特异性

Marzolini, Nicolas; Brysgel, Taylor V; Rahman, Ryan J; Essien, Eno-Obong; Nwe, Saw Y; Wu, Jichuan; Majumder, Aparajeeta; Patel, Manthan N; Tiwari, Sachchidanand; Espy, Carolann L; Dong, Fengyi; Santos-De León, Sabrina A; Shah, Anit; Shuvaev, Vladimir V; Hood, Elizabeth D; Chase, Liam S; Weissman, Drew; Katzen, Jeremy B; Frank, David B; Bennett, Mariko L; Marcos-Contreras, Oscar A; Myerson, Jacob W; Muzykantov, Vladimir R; Reyes-Esteves, Sahily; Brenner, Jacob S

One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development.

单组分可电离两亲性 Janus 树状聚合物作为高效 mRNA 疫苗开发的递送平台。

Ona Nathan A, Zhang Dapeng, Lindesmith Lisa C, Park Wook-Jin, Meshanni Jaclynn A, Berkihiser Sydni, Vasserman Jessica A, Toshtzar Sepideh, Moore Nathanael C, Williams Blair, Nakagawa Benjamin, Baboo Ishana, Pan Liuyan, Cheng Wanting, Mercado-López Xiomara, Bonilla-Acosta Wendy, Brewer-Jensen Paul D, Zweigart Mark R, Reyes Yaoska I, Mallory Michael L, May Samantha R, Zhou Yongfeng, Percec Virgil, Baric Ralph S, Li Yongsheng, Weissman Drew, Atochina-Vasserman Elena N

Investigating the impact of hypoxia and syncytialization on lipid nanoparticle-mediated mRNA delivery to placental cells

研究缺氧和合胞体化对脂质纳米颗粒介导的mRNA向胎盘细胞递送的影响

Young, Rachel E; Vijayakumar, Tara; Reilley, Logan J; Darji, Krisha; Patel, Diya; Hofbauer, Samuel; Alameh, Mohamad-Gabriel; Weissman, Drew; Riley, Rachel

Evaluation of an H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccine in lactating dairy cows

在泌乳奶牛中评估H5流感病毒mRNA-脂质纳米颗粒(LNP)疫苗

Santos, Jefferson J S; Souza, Carine K; Zanella, Giovana C; Goulart, Débora B; Arruda, Bailey; Boggiatto, Paola; Palmer, Mitchell V; Snyder, Celeste A; Kristula, Michaela A; Dickens, Charlene; Webb, Terry L; Atkinson, Reilly K; Dadonaite, Bernadeta; Dwivedi, Garima; Alameh, Mohamad-Gabriel; Bloom, Jesse D; Weissman, Drew; Althouse, Gary C; Baker, Amy L; Hensley, Scott E

RNA chemistry and therapeutics

RNA化学与治疗学

Wang, Siyu; Weissman, Drew; Dong, Yizhou

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia.

胎盘趋向性 VEGF mRNA 脂质纳米颗粒可改善小鼠先兆子痫

Swingle Kelsey L, Hamilton Alex G, Safford Hannah C, Geisler Hannah C, Thatte Ajay S, Palanki Rohan, Murray Amanda M, Han Emily L, Mukalel Alvin J, Han Xuexiang, Joseph Ryann A, Ghalsasi Aditi A, Alameh Mohamad-Gabriel, Weissman Drew, Mitchell Michael J

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses

IL-12 mRNA-LNP佐剂可增强mRNA疫苗诱导的CD8 T细胞反应

Aunins, Emily A; Phan, Anthony T; Alameh, Mohamad-Gabriel; Dwivedi, Garima; Cruz-Morales, Elisa; Christian, David A; Tam, Ying; Bunkofske, Molly E; Peñafiel, Anabel Zabala; O'Dea, Keenan M; Merolle, Maria; Furey, Colleen; Scott, Phillip; Vonderheide, Robert H; Hensley, Scott E; Kedl, Ross M; Weissman, Drew; Hunter, Christopher A

Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen

利用多臂辅助设计树枝状可降解电离脂质体,促进mRNA向脾脏的系统性递送

Xue, Lulu; Xiong, Xinhong; Zhao, Gan; Molina-Arocho, William; Palanki, Rohan; Xiao, Zebin; Han, Xuexiang; Yoon, Il-Chul; Figueroa-Espada, Christian G; Xu, Junchao; Gong, Ningqiang; Shi, Qiangqiang; Chen, Qinyuan; Alameh, Mohamad-Gabriel; Vaughan, Andrew E; Haldar, Malay; Wang, Karin; Weissman, Drew; Mitchell, Michael J

Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.

非稳定型 SARS-CoV-2 刺突 mRNA 疫苗可在非人灵长类动物中诱导产生广谱中和抗体。

Malewana R Dilshan, Stalls Victoria, May Aaron, Lu Xiaozhi, Martinez David R, Schäfer Alexandra, Li Dapeng, Barr Maggie, Sutherland Laura L, Lee Esther, Parks Robert, Beck Whitney Edwards, Newman Amanda, Bock Kevin W, Minai Mahnaz, Nagata Bianca M, DeMarco C Todd, Denny Thomas N, Oguin Thomas H 3rd, Rountree Wes, Wang Yunfei, Mansouri Katayoun, Edwards Robert J, Smith Lena, Sempowski Gregory D, Eaton Amanda, Muramatsu Hiromi, Henderson Rory, Tam Ying, Barbosa Christopher, Tang Juanjie, Cain Derek W, Santra Sampa, Moore Ian N, Andersen Hanne, Lewis Mark G, Golding Hana, Seder Robert, Khurana Surender, Montefiori David C, Pardi Norbert, Weissman Drew, Baric Ralph S, Acharya Priyamvada, Haynes Barton F, Saunders Kevin O