日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for pseudokinase-mediated regulation of GCN2 in the integrated stress response

假激酶介导的GCN2在整合应激反应中的调控的结构基础

Liu, Yixin; Misra, Jagannath; Bhowmik, Debarshi Ryan; O'Boyle, Brady; Staschke, Kirk A; Kannan, Natarajan; Wek, Ronald C; Jura, Natalia

Weight Loss During Obesity Provokes Asparaginase-Associated Liver Steatosis and Endoplasmic Reticulum Stress.

肥胖期间的体重减轻会引发天冬酰胺酶相关的肝脂肪变性和内质网应激。

Bhavsar Chintan T, Zalma Brian A, Tomoo Keigo, Zhang Yi, Lopez Esther M, Mirek Emily T, Dixon Joseph L, Henderson Gregory C, Wek Ronald C, Anthony Tracy G

A three-stage assembly program governing pancreatic, plasma, pituitary, and bone secretory cell differentiation: A strategy to augment protein delivery

调控胰腺、血浆、垂体和骨分泌细胞分化的三阶段组装程序:一种增强蛋白质递送的策略

Bidwell, Joseph P; Robling, Alexander G; Wek, Ronald C

PERK protein kinase facilitates keratinocyte collective cell migration by engagement with cell adhesion molecules, independent of its kinase activity

PERK蛋白激酶通过与细胞黏附分子结合,促进角质形成细胞的集体迁移,而这一过程与其激酶活性无关。

Diaz, Miguel Barriera; Staschke, Kirk A; Baucum, Anthony J 2nd; Spandau, Dan F; Wek, Ronald C

Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response

冷冻电镜揭示了ASX-173如何抑制人天冬酰胺合成酶以激活整合应激反应。

Staschke, Kirk A; Walda, Nicholas T; Pearce, Lucciano A; Wek, Ronald C; Zhu, Wen; Takagi, Yuichiro

GCN2 drives diurnal patterns in the hepatic integrated stress response and maintains circadian rhythms in whole body metabolism during amino acid insufficiency.

GCN2 驱动肝脏综合应激反应的昼夜节律模式,并在氨基酸不足时维持全身代谢的昼夜节律

Levy Jordan L, Mirek Emily T, Rodriguez Esther M, Tolentino Maria J, Zalma Brian A, Roepke Troy A, Wek Ronald C, Cao Ruifeng, Anthony Tracy G

321 Application of the Fick Principle for the study of visceral nutrient absorption and metabolism

321 菲克原理在内脏营养吸收和代谢研究中的应用

Konrad, Christian; Wek, Ronald C; Sullivan, William J Jr; Harmon, David L; Huntington, Gerald B

Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response

应对压力:转化控制与整合应激反应

Wek, Ronald C; Anthony, Tracy G; Staschke, Kirk A

Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones

在普拉德-威利综合征β细胞模型中,胰岛素分泌缺陷与多种内质网分子伴侣的协同下调有关。

Koppes, Erik A; Johnson, Marie A; Moresco, James J; Luppi, Patrizia; Lewis, Dale W; Stolz, Donna B; Diedrich, Jolene K; Yates, John R 3rd; Wek, Ronald C; Watkins, Simon C; Gollin, Susanne M; Park, Hyun Jung; Drain, Peter; Nicholls, Robert D

Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

激活转录因子4 (ATF4) 的生物学特性及其在骨骼肌萎缩中的作用

Ebert, Scott M; Rasmussen, Blake B; Judge, Andrew R; Judge, Sarah M; Larsson, Lars; Wek, Ronald C; Anthony, Tracy G; Marcotte, George R; Miller, Matthew J; Yorek, Mark A; Vella, Adrian; Volpi, Elena; Stern, Jennifer I; Strub, Matthew D; Ryan, Zachary; Talley, John J; Adams, Christopher M