日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Nanoscale Direct-to-Biology Optimization and Structural Insights into Selective S. aureus TrmD Inhibitors

纳米尺度直接生物优化及选择性金黄色葡萄球菌TrmD抑制剂的结构解析

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02323
Hübner, Ariane F; Weldert, Annabelle C; Marciniak, Tessa; Hof, Florian; Beck, Vivien S; Carien, Samuel; Mulartschyk, Sophie N; Wolf, Eva; Ziebuhr, Wilma; Barthels, Fabian
发表日期：2025
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A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors

基于微尺度热泳的酶促RNA甲基转移酶检测方法能够发现DNMT2抑制剂

期刊:Communications Chemistry
影响因子:6.2
doi:10.1038/s42004-025-01439-9
Nidoieva, Zarina; Sabin, Mark O; Dewald, Tristan; Weldert, Annabelle C; Hoba, Sabrina N; Helm, Mark; Barthels, Fabian
发表日期：2025
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DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site.

DNA编码文库筛选发现了靶向隐蔽变构结合位点的强效DNMT2抑制剂

期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2025.113300
Frey Ariane F, Schwan Merlin, Weldert Annabelle C, Kadenbach Valerie, Kopp Jürgen, Nidoieva Zarina, Zimmermann Robert A, Gleue Lukas, Zimmer Collin, Jörg Marko, Friedland Kristina, Helm Mark, Sinning Irmgard, Barthels Fabian
其它
发表日期：2025
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Parallel synthesis of 5'-amino-5'-deoxy-adenosine derivatives for focused chemical space exploration and their application as methyltransferase inhibitors

5'-氨基-5'-脱氧腺苷衍生物的平行合成及其在聚焦化学空间探索中的应用及其作为甲基转移酶抑制剂的应用

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00376h
Hoba, Sabrina N; Schwickert, Marvin; Kammerer, Luis; Sabin, Mark; Weldert, Annabelle C; Nidoieva, Zarina; Meidner, J Laurenz; Barthels, Fabian; Schirmeister, Tanja; Kersten, Christian
发表日期：2025
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Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype.

结构导向设计甲基转移酶样 3 (METTL3) 蛋白水解靶向嵌合体 (PROTAC)，其中包含吲哚-烟酰胺化学类型

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00359h
Weldert Annabelle C, Frey Ariane F, Krone Mackenzie W, Krähe Franziska, Kuhn Hannah, Kersten Christian, Barthels Fabian
免疫/内分泌
发表日期：2025
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Identification of Dual Inhibitors Targeting Main Protease (M(pro)) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents

鉴定靶向主蛋白酶（M(pro)）和组织蛋白酶L的双重抑制剂作为潜在的抗SARS-CoV-2药物

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.3c00562
Previti, Santo; Ettari, Roberta; Calcaterra, Elsa; Roggia, Michele; Natale, Benito; Weldert, Annabelle C; Müller-Ruttloff, Christin; Salisch, Florian; Irto, Anna; Cigala, Rosalia Maria; Ziebuhr, John; Schirmeister, Tanja; Cosconati, Sandro; Zappalà, Maria
SARS-CoV-2
发表日期：2024
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