日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

对人类短尾蛋白DNA识别的结构性见解以及用于癌症治疗的新型结合剂的发现

Newman, Joseph A; Gavard, Angeline E; Imprachim, Nergis; Aitkenhead, Hazel; Sheppard, Hadley E; Te Poele, Robert; Clarke, Paul A; Hossain, Mohammad Anwar; Temme, Louisa; Oh, Hans J; Wells, Carrow I; Davis-Gilbert, Zachary W; Workman, Paul; Gileadi, Opher; Drewry, David H

Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

利用定量构效关系发现和优化窄谱Tousled样激酶2 (TLK2) 抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

利用定量构效关系发现和优化Tousled样激酶2(TLK2)的窄谱抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

丝氨酸/苏氨酸激酶细胞周期蛋白依赖性激酶样蛋白5 (CDKL5) 特异性抑制剂的发现和表征揭示了其在海马CA1区生理功能中的作用。

Castano, Anna; Silvestre, Margaux; Wells, Carrow I; Sanderson, Jennifer L; Ferrer, Carla A; Ong, Han Wee; Lang, Yi; Richardson, William; Silvaroli, Josie A; Bashore, Frances M; Smith, Jeffery L; Genereux, Isabelle M; Dempster, Kelvin; Drewry, David H; Pabla, Navlot S; Bullock, Alex N; Benke, Tim A; Ultanir, Sila; Axtman, Alison D

Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds

用于生物活性化合物自动从头设计的生成式和强化学习方法

Korshunova, Maria; Huang, Niles; Capuzzi, Stephen; Radchenko, Dmytro S; Savych, Olena; Moroz, Yuriy S; Wells, Carrow I; Willson, Timothy M; Tropsha, Alexander; Isayev, Olexandr

Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype

鉴定 4-苯胺基喹啉(唑)啉为细胞活性蛋白激酶新型 3 (PKN3) 抑制剂化学型

Asquith, Christopher R M; Temme, Louisa; East, Michael P; Laitinen, Tuomo; Pickett, Julie; Kwarcinski, Frank E; Sinha, Parvathi; Wells, Carrow I; Johnson, Gary L; Zutshi, Reena; Drewry, David H

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

激酶化学基因组学数据集(KCGS):用于识别激酶脆弱性的开放科学资源

Wells, Carrow I; Al-Ali, Hassan; Andrews, David M; Asquith, Christopher R M; Axtman, Alison D; Dikic, Ivan; Ebner, Daniel; Ettmayer, Peter; Fischer, Christian; Frederiksen, Mathias; Futrell, Robert E; Gray, Nathanael S; Hatch, Stephanie B; Knapp, Stefan; Lücking, Ulrich; Michaelides, Michael; Mills, Caitlin E; Müller, Susanne; Owen, Dafydd; Picado, Alfredo; Saikatendu, Kumar S; Schröder, Martin; Stolz, Alexandra; Tellechea, Mariana; Turunen, Brandon J; Vilar, Santiago; Wang, Jinhua; Zuercher, William J; Willson, Timothy M; Drewry, David H

A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.

一种用于暗激酶 STK17B 的化学探针,其高效性和高选择性源于其独特的 P 环构象

Picado Alfredo, Chaikuad Apirat, Wells Carrow I, Shrestha Safal, Zuercher William J, Pickett Julie E, Kwarcinski Frank E, Sinha Parvathi, de Silva Chandi S, Zutshi Reena, Liu Shubin, Kannan Natarajan, Knapp Stefan, Drewry David H, Willson Timothy M

Donated chemical probes for open science

捐赠化学探针用于开放科学

Müller, Susanne; Ackloo, Suzanne; Arrowsmith, Cheryl H; Bauser, Marcus; Baryza, Jeremy L; Blagg, Julian; Böttcher, Jark; Bountra, Chas; Brown, Peter J; Bunnage, Mark E; Carter, Adrian J; Damerell, David; Dötsch, Volker; Drewry, David H; Edwards, Aled M; Edwards, James; Elkins, Jon M; Fischer, Christian; Frye, Stephen V; Gollner, Andreas; Grimshaw, Charles E; IJzerman, Adriaan; Hanke, Thomas; Hartung, Ingo V; Hitchcock, Steve; Howe, Trevor; Hughes, Terry V; Laufer, Stefan; Li, Volkhart Mj; Liras, Spiros; Marsden, Brian D; Matsui, Hisanori; Mathias, John; O'Hagan, Ronan C; Owen, Dafydd R; Pande, Vineet; Rauh, Daniel; Rosenberg, Saul H; Roth, Bryan L; Schneider, Natalie S; Scholten, Cora; Singh Saikatendu, Kumar; Simeonov, Anton; Takizawa, Masayuki; Tse, Chris; Thompson, Paul R; Treiber, Daniel K; Viana, Amélia Yi; Wells, Carrow I; Willson, Timothy M; Zuercher, William J; Knapp, Stefan; Mueller-Fahrnow, Anke

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

鉴定和优化4-苯胺基喹啉类化合物作为细胞周期蛋白G相关激酶抑制剂

Asquith, Christopher R M; Laitinen, Tuomo; Bennett, James M; Godoi, Paulo H; East, Michael P; Tizzard, Graham J; Graves, Lee M; Johnson, Gary L; Dornsife, Ronna E; Wells, Carrow I; Elkins, Jonathan M; Willson, Timothy M; Zuercher, William J