Wen Zhexing相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome

整合转录组关联分析揭示PRKCG基因相关的GABA能功能障碍与脆性X染色体相关震颤/共济失调综合征有关

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-68163-9

Jin, Yulin; Cao, Yiqu; Ma, Wenjing; Li, Ronghua; Li, Yujing; Kang, Yunhee; Huang, Jing; Epstein, Michael P; Guo, Xiangxue; Lim, Junghwa; Rivera, Natalia; Zhou, Ying; Wen, Zhexing; Allen, Emily G; Jin, Peng

发表日期：2026

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Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons

白细胞介素-6对人诱导多能干细胞来源的多巴胺能神经元的突触效应

期刊:Neuropsychopharmacology

影响因子:7.1

doi:10.1038/s41386-025-02320-y

Huang, Yiqi; Michalski, Christina; Zhou, Ying; Xu, Chongchong; Niu, Weibo; Lucido, Michael J; Wang, Jianjun; Feng, Yue; Miller, Andrew H; Wen, Zhexing

细胞生物学

发育与干细胞

发表日期：2026

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Loss of ATM causes R-loop-associated transcriptional dysregulation and attenuates the related response to DNA damage.

ATM 的缺失会导致 R 环相关的转录失调，并减弱对 DNA 损伤的相关反应。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2026.111161

Westover Katherine R, Hou Yingzi, Wang Feng, Wang Yilin, Li Yangping, Seong Rachel, Xu Jie, Wen Zhexing, Yao Bing

发表日期：2026

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Cell type-resolved proteomics reveals intra- and intercellular signaling in Alzheimer's disease

细胞类型分辨蛋白质组学揭示阿尔茨海默病中的细胞内和细胞间信号传导

doi:10.64898/2026.02.02.703357

Zhang, Xue; Yu, Kaiwen; Shrestha, Him K; Zhou, Ying; Yang, Jiyuan; Wang, Zhen; Ren, Xiaokang; Chen, Ping-Chung; Sun, Huan; Liu, Danting; Jiao, Yun; Yarbro, Jay M; Wang, Ju; Wu, Zhiping; Harper, Kiara; He, Liusheng; Yuan, Zuo-Fei; Wang, Xusheng; High, Anthony A; Yu, Gang; Yu, Jiyang; Wen, Zhexing; Peng, Junmin

阿尔茨海默症

细胞生物学

发表日期：2026

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Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology.

开发一种可穿透血脑屏障的 G9a 甲基化酶抑制剂，以靶向治疗阿尔茨海默病相关的蛋白质病理

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-59128-z

Xie Ling, Sheehy Ryan N, Muneer Adil, Xiong Yan, Wrobel John A, Zhang Feng, Park Kwang-Su, Velez Julia, Liu Jing, Luo Yan-Jia, Asrican Brent, Dong Ping, Li Ya-Dong, Damian Corina, Quintanilla Luis, Li Yongyi, Xu Chongchong, Deshmukh Mohanish, Coleman Leon G Jr, Ming Guo-Li, Song Hongjun, Wen Zhexing, Jin Jian, Song Juan, Chen Xian

发表日期：2025

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Analyses of GWAS and Sub-Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

全基因组关联研究（GWAS）和亚阈值位点分析揭示了树突发育和形态功能障碍是精神分裂症遗传风险的潜在机制。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202508519

Chen, Rui; Siciliano, Benjamin; Wang, Quan; Xu, Chongchong; Wei, Qiang; Yang, Hai; Sutcliffe, James S; Jiang, Yi; Ji, Ying; Liu, Chunyu; Cheng, Feixiong; Cook, Edwin H; Cox, Nancy J; Zhong, Xue; Wen, Zhexing; Li, Bingshan

精神分裂症

发育与干细胞

发表日期：2025

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A non-coding RNA risk pathway in schizophrenia: miR-137 enhances the lncRNA GOMAFU through a pathological transcription network.

精神分裂症中的非编码 RNA 风险通路：miR-137 通过病理转录网络增强 lncRNA GOMAFU。

期刊:Translational Psychiatry

影响因子:6.2

doi:10.1038/s41398-025-03709-5

Teng Peng, Zhou Ying, Ji Xingyu, Li Yangping, Ku Li, Wang Feng, Wen Zhexing, Yao Bing, Feng Yue

精神分裂症

发表日期：2025

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Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology

患者来源的脑膜瘤类器官：研究人类肿瘤病理生理学的可靠模型

影响因子:4.4

doi:10.3390/cancers17030526

Zohdy, Youssef M; Jahangiri, Arman; Jacob, Fadi; Aksionau, Aliaksandr; Alawieh, Ali M; Tong, Amelia; Chern, Bethany; Maldonado, Justin; Hoang, Kimberly; Nduom, Edjah; Howard, Brian M; Barrow, Daniel L; Neill, Stewart G; Wen, Zhexing; Pradilla, Gustavo; Garzon-Muvdi, Tomas

发表日期：2025

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Integrative transcriptomics and network analysis reveals core genes driving meningioma pathogenesis and clinical outcomes

整合转录组学和网络分析揭示了驱动脑膜瘤发病机制和临床结局的核心基因

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-29334-2

Zohdy, Youssef M; Alawieh, Ali M; Jahangiri, Arman; Siciliano, Benjamin; Tariciotti, Leonardo; Rodas, Alejandra; Maldonado, Justin; Hoang, Kimberly; Nduom, Edjah; Howard, Brian M; Barrow, Daniel L; Aksionau, Aliaksandr; Neill, Stewart G; Wen, Zhexing; Pradilla, Gustavo; Garzon-Muvdi, Tomas

发表日期：2025

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Tensor decomposition of multi-dimensional splicing events across multiple tissues to identify splicing-mediated risk genes associated with complex traits

对跨多个组织的多维剪接事件进行张量分解，以识别与复杂性状相关的剪接介导风险基因

期刊:PLoS Computational Biology

影响因子:3.6

doi:10.1371/journal.pcbi.1013303

Yan, Yan; Chen, Rui; Kang, Hakmook; Tan, Yuting; Tiwari, Anshul; Ma, Siyuan; Wen, Zhexing; Zhong, Xue; Li, Bingshan

发表日期：2025

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