Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents
发现、合成和评估氧硝基丁啶衍生物作为 DNA 拓扑异构酶 IB (TOP1) 和酪氨酰-DNA 磷酸二酯酶 1 (TDP1) 双重抑制剂以及潜在的抗肿瘤药物
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.8b00639
Xiao-Ru Zhang, Hao-Wen Wang, Wen-Lin Tang, Yu Zhang, Hui Yang, De-Xuan Hu, Azhar Ravji, Christophe Marchand, Evgeny Kiselev, Kwabena Ofori-Atta, Keli Agama, Yves Pommier, Lin-Kun An
