日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proteomic analysis links truncated tau to lysosome motility, autophagy, and endo-lysosomal dysfunction

蛋白质组学分析表明,截短的tau蛋白与溶酶体运动、自噬和内溶酶体功能障碍有关。

Despoina Goniotaki,Maximilian Hausherr ,Steven Lynham,Ayushin Ale,George Chennell,Stefania Marcotti,Katrin Marcus ,Wendy Noble,Diane P Hanger,Graham Fraser,Deepak P Srivastava

Tau-mediated synaptic dysfunction is coupled with HCN channelopathy

Tau 介导的突触功能障碍与 HCN 通道病有关

Despoina Goniotaki, Francesco Tamagnini, Luca Biasetti, Svenja-Lotta Rumpf, Claire Troakes, Saskia J Pollack, Shalom Ukwesa, Haoyue Sun, Igor Kraev, Louise C Serpell, Wendy Noble, Kevin Staras, Diane P Hanger

Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection

反应性星形胶质细胞分泌分子伴侣HSPB1以介导神经保护作用

Fangjia Yang ,Paula Beltran-Lobo ,Katherine Sung ,Caoimhe Goldrick ,Cara L Croft ,Agnes Nishimura ,Erin Hedges ,Farah Mahiddine ,Claire Troakes ,Todd E Golde ,Beatriz G Perez-Nievas ,Diane P Hanger ,Wendy Noble ,Maria Jimenez-Sanchez

Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation

截短的tau蛋白会干扰自噬和内溶酶体途径,导致脂质积累。

Saskia J Pollack,Dina Dakkak,Tong Guo,George Chennell,Patricia Gomez-Suaga,Wendy Noble,Maria Jimenez-Sanchez,Diane P Hanger

Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects

刺激 VAPB-PTPIP51 ER-线粒体束缚可纠正 FTD/ALS 突变体 TDP43 关联的 Ca2+ 和突触缺陷

Andrea Markovinovic #, Sandra M Martín-Guerrero #, Gábor M Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C Mitchell, Wendy Noble, Christopher C J Miller

P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes

P2X7R影响人类tau蛋白病中的tau蛋白聚集负荷,并在小胶质细胞和星形胶质细胞中表现出不同的信号传导。

Paula Beltran-Lobo ,Martina M Hughes ,Claire Troakes ,Cara L Croft ,Huzefa Rupawala ,Daniel Jutzi ,Marc-David Ruepp ,Maria Jimenez-Sanchez ,Michael S Perkinton ,Michael Kassiou ,Todd E Golde ,Diane P Hanger ,Alexei Verkhratsky ,Beatriz G Perez-Nievas ,Wendy Noble

Proteomics of the astrocyte secretome reveals changes in their response to soluble oligomeric Aβ

星形胶质细胞分泌蛋白组的蛋白质组学揭示了它们对可溶性寡聚 Aβ 的反应变化

Vittoria Matafora, Alena Gorb, Fangjia Yang, Wendy Noble, Angela Bachi, Beatriz Gomez Perez-Nievas, Maria Jimenez-Sanchez

Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia

C9orf72 相关肌萎缩侧索硬化症和额颞叶痴呆症中内质网线粒体连接和信号传导中断

Patricia Gomez-Suaga, Gábor M Mórotz, Andrea Markovinovic, Sandra M Martín-Guerrero, Elisavet Preza, Natalia Arias, Keith Mayl, Afra Aabdien, Vesela Gesheva, Agnes Nishimura, Ambra Annibali, Younbok Lee, Jacqueline C Mitchell, Selina Wray, Christopher Shaw, Wendy Noble, Christopher C J Miller

Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis

人类肌萎缩侧索硬化症死后 VAPB-PTPIP51 ER-线粒体束缚蛋白的破坏

Naomi Hartopp, Dawn H W Lau, Sandra M Martin-Guerrero, Andrea Markovinovic, Gábor M Mórotz, Jenny Greig, Elizabeth B Glennon, Claire Troakes, Patricia Gomez-Suaga, Wendy Noble, Christopher C J Miller

Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease

半胱氨酸丝蛋白α在阿尔茨海默病早期突触前功能障碍中积累

Huzefa Rupawala ,Keshvi Shah ,Caitlin Davies ,Jamie Rose ,Marti Colom-Cadena ,Xianhui Peng ,Lucy Granat ,Manal Aljuhani ,Keiko Mizuno ,Claire Troakes ,Beatriz Gomez Perez-Nievas ,Alan Morgan ,Po-Wah So ,Tibor Hortobagyi ,Tara L Spires-Jones ,Wendy Noble ,Karl Peter Giese