日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety of intratumoral immunostimulatory LOAd703 gene therapy combined with chemotherapy in patients with advanced cancer

肿瘤内免疫刺激性LOAd703基因疗法联合化疗治疗晚期癌症患者的安全性

Hahn, A; Irenaeus, S; Sandin, L C; Wenthe, J; Eriksson, E; Jarblad, J L; Schiza, A; Dahlstrand, H; Olsson-Strömberg, U; Krause, J; Sundin, A; Loskog, A; Ullenhag, G J

LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study

LOAd703(一种基于溶瘤病毒的免疫刺激基因疗法)联合化疗治疗不可切除或转移性胰腺癌(LOKON001):一项非随机、单中心、1/2期研究的第1组结果

Musher, Benjamin L; Rowinsky, Eric K; Smaglo, Brandon G; Abidi, Wasif; Othman, Mohamed; Patel, Kalpesh; Jawaid, Salmaan; Jing, James; Brisco, Amanda; Leen, Ann M; Wu, Mengfen; Sandin, Linda C; Wenthe, Jessica; Eriksson, Emma; Ullenhag, Gustav J; Grilley, Bambi; Leja-Jarblad, Justyna; Hilsenbeck, Susan G; Brenner, Malcolm K; Loskog, Angelica S I

CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling

CD40配体介导的CD40刺激可增强腺病毒介导的肿瘤免疫原性,包括“找到我”、“吃掉我”和“杀死我”信号传导。

Naseri, Sedigheh; Cordova, Mariela Mejia; Wenthe, Jessica; Lövgren, Tanja; Eriksson, Emma; Loskog, Angelica; Ullenhag, Gustav J

Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy

高效多重非病毒改造及扩增多克隆γδCAR-T细胞用于免疫治疗

Jacob Bridge, Matthew J Johnson, Jihyun Kim, Sophia Wenthe, Joshua Krueger, Bryce Wick, Mitchell Kluesner, Andrew T Crane, Jason Bell, Joseph G Skeate, Branden S Moriarity, Beau R Webber

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

靶向 CD40、4-1BB 和 IL-2R 的免疫刺激基因疗法可激活树突状细胞 (DC),并在黑色素瘤模型中刺激抗原特异性 T 细胞和 NK 细胞反应。

Jessica Wenthe ,Emma Eriksson ,Ann-Charlotte Hellström ,Rafael Moreno ,Gustav Ullenhag ,Ramon Alemany ,Tanja Lövgren ,Angelica Loskog

Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition

利用靶向DC细胞和T细胞的基因疗法进行免疫启动,可使已治疗的和远处转移的B16肿瘤对检查点抑制剂更加敏感。

Wenthe, Jessica; Naseri, Sedigheh; Hellström, Ann-Charlotte; Moreno, Rafael; Ullenhag, Gustav; Alemany, Ramon; Lövgren, Tanja; Eriksson, Emma; Loskog, Angelica

Dystrophin missense mutations alter focal adhesion tension and mechanotransduction

肌营养不良蛋白错义突变改变粘着斑张力和机械转导

Maria Paz Ramirez, Michael J M Anderson, Marcus D Kelly, Lauren J Sundby, Anthony R Hagerty, Sophia J Wenthe, David J Odde, James M Ervasti, Wendy R Gordon

Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy

利用溶瘤病毒基因疗法同时靶向 CD40/4-1BB 来增强淋巴瘤中的 CAR T 细胞反应

Jessica Wenthe ,Sedigheh Naseri ,Alireza Labani-Motlagh ,Gunilla Enblad ,Kristina I Wikström ,Emma Eriksson ,Angelica Loskog # ,Tanja Lövgren #

Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes

肿瘤来源的外泌体可能支持携带免疫刺激基因的局部溶瘤病毒治疗后的全身免疫

Alireza Labani-Motlagh, Sedigheh Naseri, Jessica Wenthe, Emma Eriksson, Angelica Loskog

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

针对 4-1BB 和/或 CD40 的免疫刺激性溶瘤病毒疗法治疗多发性骨髓瘤

Jessica Wenthe ,Sedigheh Naseri ,Ann-Charlotte Hellström ,Helena Jernberg Wiklund ,Emma Eriksson ,Angelica Loskog