日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models

BRD-810 是一种高选择性 MCL1 抑制剂,具有优化的体内清除率,在实体肿瘤和血液肿瘤模型中具有强大的疗效

Ulrike Rauh, Guo Wei, Michael Serrano-Wu, Georgios Kosmidis, Stefan Kaulfuss, Franziska Siegel, Kai Thede, James McFarland, Christopher T Lemke, Nicolas Werbeck, Katrin Nowak-Reppel, Sabine Pilari, Stephan Menz, Matthias Ocker, Weiqun Zhang, Kyle Davis, Guillaume Poncet-Montange, Jennifer Roth, Doug

A distal regulatory region of a class I human histone deacetylase

类人类组蛋白去乙酰化酶的远端调节区

Nicolas D Werbeck #, Vaibhav Kumar Shukla #, Micha B A Kunze, Havva Yalinca, Ruth B Pritchard, Lucas Siemons, Somnath Mondal, Simon O R Greenwood, John Kirkpatrick, Charles M Marson, D Flemming Hansen

Identification of Small Molecules that Modulate Mutant p53 Condensation

鉴定调节突变型p53凝聚的小分子

Lemos, Clara; Schulze, Luise; Weiske, Joerg; Meyer, Hanna; Braeuer, Nico; Barak, Naomi; Eberspächer, Uwe; Werbeck, Nicolas; Stresemann, Carlo; Lange, Martin; Lesche, Ralf; Zablowsky, Nina; Juenemann, Katrin; Kamburov, Atanas; Luh, Laura Martina; Leissing, Thomas Markus; Mortier, Jeremie; Steckel, Michael; Steuber, Holger; Eis, Knut; Eheim, Ashley; Steigemann, Patrick

Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction

表征酶促磷酸转移反应轨迹中活性位点构象异质性

Zeymer, Cathleen; Werbeck, Nicolas D; Zimmermann, Sabine; Reinstein, Jochen; Hansen, D Flemming

Interleukin-6 is a potential therapeutic target in interleukin-6 dependent, estrogen receptor-α-positive breast cancer

白细胞介素-6是白细胞介素-6依赖性、雌激素受体α阳性乳腺癌的潜在治疗靶点。

Casneuf, Tineke; Axel, Amy E; King, Peter; Alvarez, John D; Werbeck, Jillian L; Verhulst, Tinne; Verstraeten, Karin; Hall, Brett M; Sasser, A Kate

Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma

在骨侵袭性口腔鳞状细胞癌的原位小鼠模型中,唑来膦酸和美洛昔康联合用药可减少骨丢失和肿瘤生长。

Martin, C K; Dirksen, W P; Carlton, M M; Lanigan, L G; Pillai, S P; Werbeck, J L; Simmons, J K; Hildreth, B E 3rd; London, C A; Toribio, R E; Rosol, T J

Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth

胶质瘤血管周围微环境中的骨桥蛋白-CD44信号通路增强癌症干细胞表型并促进肿瘤侵袭性生长。

Pietras, Alexander; Katz, Amanda M; Ekström, Elin J; Wee, Boyoung; Halliday, John J; Pitter, Kenneth L; Werbeck, Jillian L; Amankulor, Nduka M; Huse, Jason T; Holland, Eric C

Using ¹⁵N-ammonium to characterise and map potassium binding sites in proteins by NMR spectroscopy

使用 ¹⁵N-铵通过核磁共振光谱法表征和绘制蛋白质中的钾结合位点

Nicolas D Werbeck, John Kirkpatrick, Jochen Reinstein, D Flemming Hansen

Heteronuclear transverse and longitudinal relaxation in AX4 spin systems: application to (15)N relaxations in (15)NH4(+)

AX4 自旋系统中的异核横向和纵向弛豫:应用于 (15)NH4(+) 中的 (15)N 弛豫

Werbeck, Nicolas D; Hansen, D Flemming

Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-PymT mammary cancer cells in vivo

肿瘤微环境在体内调控小鼠MMTV-PymT乳腺癌细胞的转移及其相关基因

Werbeck, J L; Thudi, N K; Martin, C K; Premanandan, C; Yu, L; Ostrowksi, M C; Rosol, T J