Small-molecule inhibitor of Câterminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells.
C端HSP90二聚化的小分子抑制剂可调节自噬，并与mTOR抑制剂协同作用杀死顺铂耐药癌细胞。
期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08330-4
David Céline, Sun Yadong, Woloschin Vitalij, Vogt Melina, Dienstbier Niklas, Friedrich Annabelle, Krings Karina S, Schlütermann David, Berning Lena, Lungerich Beate, Akgün Seda, Mendiburo MarÃa José, Gertzen Christoph G W, Borkhardt Arndt, Wesselborg Sebastian, Gohlke Holger, Bhatia Sanil, Kurz Thomas, Stork Björn
细胞生物学
MTOR
HSP90
Autophagy
mTOR
自噬
