日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cell-State-Specific Drug Responses are Associated With Differences in Signaling Network Wiring

细胞状态特异性药物反应与信号网络连接的差异相关

Krämer, Niels; van Eijl, Roderick; Stohn, Tim; Tanis, Sabine; Wessels, Lodewyk Fa; Bosdriesz, Evert; Mulder, Klaas W

Reconstructing and comparing signal transduction networks from single-cell protein quantification data

利用单细胞蛋白质定量数据重建和比较信号转导网络

Stohn, Tim; van Eijl, Roderick A P M; Mulder, Klaas W; Wessels, Lodewyk F A; Bosdriesz, Evert

Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers.

错配修复功能正常的结肠癌的新辅助免疫疗法。

Tan Pedro B, Verschoor Yara L, van den Berg José G, Balduzzi Sara, Kok Niels F M, Ijsselsteijn Marieke E, Moore Kat, Jurdi Adham, Tin Antony, Kaptein Paulien, van Leerdam Monique E, Haanen John B A G, Voest Emile E, de Miranda Noel F C C, Schumacher Ton N, Wessels Lodewyk F A, Chalabi Myriam

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.

CDS1 和 CDS2 之间的合成致死相互作用是葡萄膜黑色素瘤以及多种肿瘤类型的弱点

Chan Pui Ying, Alexander Diana, Mehta Ishan, Matsuyama Larissa Satiko Alcantara Sekimoto, Harle Victoria, Olvera-León Rebeca, Park Jun Sung, Arriaga-González Fernanda G, van der Weyden Louise, Cheema Saamin, Iyer Vivek, Offord Victoria, Barneda David, Hawkins Phillip T, Stephens Len, Kozik Zuza, Woods Michael, Wong Kim, Balmus Gabriel, Vinceti Alessandro, Thompson Nicola A, Del Castillo Velasco-Herrera Martin, Wessels Lodewyk, van de Haar Joris, Gonçalves Emanuel, Sinha Sanju, Vázquez-Cruz Martha Estefania, Bisceglia Luisa, Raimondi Francesco, Choudhary Jyoti, Patiyal Sumeet, Venkatesh Anjan, Iorio Francesco, Ryan Colm J, Adams David J

Whole genome sequencing of 378 prostate cancer metastases reveals tissue selectivity for mismatch deficiency with potential therapeutic implications

对 378 例前列腺癌转移灶进行全基因组测序,揭示了错配缺失的组织选择性,这可能具有治疗意义。

Vis, Daniel J; Palit, Sander A L; Corradi, Marie; Cuppen, Edwin; Mehra, Niven; Lolkema, Martijn P; Wessels, Lodewyk F A; van der Heijden, Michiel S; Zwart, Wilbert; Bergman, Andries M

CfDNA-based copy-number dynamics during anti-PD1 treatment in metastatic triple negative breast cancer

转移性三阴性乳腺癌抗PD-1治疗期间基于cfDNA的拷贝数动态变化

Lin, Aaron Y; Isaeva, Olga I; Deger, Teoman; Geurts, Veerle C M; Vessies, Daan C L; Voorwerk, Leonie; Slagter, Maarten; Moore, Kat S; van der Leest, Paul; Martens, John W M; van den Broek, Daan; Wessels, Lodewyk F A; Kok, Marleen

Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.

表观遗传分析可识别内分泌耐药性标志物,并为转移性去势抵抗性前列腺癌提供治疗选择

Severson Tesa M, Minnee Emma, Zhu Yanyun, Schuurman Karianne, Nguyen Holly M, Brown Lisha G, Hakkola Sini, Menezes Renee, Gregoricchio Sebastian, Kim Yongsoo, Kneppers Jeroen, Linder Simon, Stelloo Suzan, Lieftink Cor, van der Heijden Michiel S, Nykter Matti, van der Noort Vincent, Sanders Joyce, Morris Ben, Jenster Guido, van Leenders Geert Jlh, Pomerantz Mark, Freedman Matthew L, Beijersbergen Roderick L, Urbanucci Alfonso, Wessels Lodewyk, Nelson Peter S, Corey Eva, Prekovic Stefan, Zwart Wilbert, Bergman Andries M

Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations.

子宫内膜肿瘤发生涉及表观遗传可塑性,区分非编码体细胞突变和 3D 基因组改变

Gregoricchio Sebastian, Kojic Aleksandar, Hoogstraat Marlous, Schuurman Karianne, Stelloo Suzan, Severson Tesa M, O'Mara Tracy A, Droog Marjolein, Singh Abhishek A, Glubb Dylan M, Wessels Lodewyk F A, Vermeulen Michiel, van Leeuwen Flora E, Zwart Wilbert

A pan-cancer screen identifies drug combination benefit in cancer cell lines at the individual and population level

泛癌筛选可在个体和群体水平上识别癌细胞系中的药物组合获益。

Vis, Daniel J; Jaaks, Patricia; Aben, Nanne; Coker, Elizabeth A; Barthorpe, Syd; Beck, Alexandra; Hall, Caitlin; Hall, James; Lightfoot, Howard; Lleshi, Ermira; Mironenko, Tatiana; Richardson, Laura; Tolley, Charlotte; Garnett, Mathew J; Wessels, Lodewyk F A

Combining Genomic Biomarkers to Guide Immunotherapy in Non-Small Cell Lung Cancer

结合基因组生物标志物指导非小细胞肺癌的免疫治疗

van de Haar, Joris; Mankor, Joanne M; Hummelink, Karlijn; Monkhorst, Kim; Smit, Egbert F; Wessels, Lodewyk F A; Cuppen, Edwin; Aerts, Joachim G J V; Voest, Emile E