日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase 1b/2 study of orally administered pexidartinib in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma

一项针对新诊断胶质母细胞瘤患者的口服pexidartinib联合放射疗法和替莫唑胺的1b/2期研究

Mendez, Joe S; Cohen, Adam L; Eckenstein, Midori; Jensen, Randy L; Burt, Lindsay M; Salzman, Karen L; Chamberlain, Marc; Hsu, Henry H; Hutchinson, Marguerite; Iwamoto, Fabio; Ligon, Keith L; Mrugala, Maciej M; Pelayo, Michael; Plotkin, Scott R; Puduvalli, Vinay K; Raizer, Jeffrey; Reardon, David A; Sterba, Michael; Walbert, Tobias; West, Brian L; Wong, Eric T; Zhang, Chao; Colman, Howard

Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT

一项评估佩西达替尼治疗六个实体瘤队列(包括睾丸生殖细胞肿瘤和睾丸生殖细胞肿瘤中CSF1转录本异常)的I期扩展研究结果

Tap, William D; Singh, Arun S; Anthony, Stephen Patrick; Sterba, Mike; Zhang, Chao; Healey, John H; Chmielowski, Bartosz; Cohn, Allen Lee; Shapiro, Geoffrey I; Keedy, Vicki L; Wainberg, Zev A; Puzanov, Igor; Cote, Gregory M; Wagner, Andrew J; Braiteh, Fadi; Sherman, Eric; Hsu, Henry H; Peterfy, Charles; Gelhorn, Heather L; Ye, Xin; Severson, Paul; West, Brian L; Lin, Paul S; Tong-Starksen, Sandra

Activated microglia drive demyelination via CSF1R signaling

活化的微胶质细胞通过CSF1R信号通路驱动脱髓鞘。

Marzan, Dave E; Brügger-Verdon, Valérie; West, Brian L; Liddelow, Shane; Samanta, Jayshree; Salzer, James L

Mitigation of helium irradiation-induced brain injury by microglia depletion

通过清除小胶质细胞减轻氦辐射引起的脑损伤

Allen, Barrett D; Syage, Amber R; Maroso, Mattia; Baddour, Al Anoud D; Luong, Valerie; Minasyan, Harutyun; Giedzinski, Erich; West, Brian L; Soltesz, Ivan; Limoli, Charles L; Baulch, Janet E; Acharya, Munjal M

Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments

减轻神经炎症可逆转阿霉素引起的认知障碍

Allen, Barrett D; Apodaca, Lauren A; Syage, Amber R; Markarian, Mineh; Baddour, Al Anoud D; Minasyan, Harutyun; Alikhani, Leila; Lu, Celine; West, Brian L; Giedzinski, Erich; Baulch, Janet E; Acharya, Munjal M

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors

一项针对晚期实体瘤患者的Ib期研究,评估了CSF-1R抑制剂pexidartinib(PLX3397)与紫杉醇联合用药的疗效。

Wesolowski, Robert; Sharma, Neelesh; Reebel, Laura; Rodal, Mary Beth; Peck, Alexandra; West, Brian L; Marimuthu, Adhirai; Severson, Paul; Karlin, David A; Dowlati, Afshin; Le, Mai H; Coussens, Lisa M; Rugo, Hope S

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms

小胶质细胞通过P2Y12信号通路控制嗜神经病毒感染的扩散,并通过不依赖于P2Y12的机制募集单核细胞。

Fekete, Rebeka; Cserép, Csaba; Lénárt, Nikolett; Tóth, Krisztina; Orsolits, Barbara; Martinecz, Bernadett; Méhes, Előd; Szabó, Bálint; Németh, Valéria; Gönci, Balázs; Sperlágh, Beáta; Boldogkői, Zsolt; Kittel, Ágnes; Baranyi, Mária; Ferenczi, Szilamér; Kovács, Krisztina; Szalay, Gergely; Rózsa, Balázs; Webb, Connor; Kovacs, Gabor G; Hortobágyi, Tibor; West, Brian L; Környei, Zsuzsanna; Dénes, Ádám

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

在小鼠衰老的大脑中替换小胶质细胞可以逆转其认知、突触和神经元缺陷。

Elmore, Monica R P; Hohsfield, Lindsay A; Kramár, Enikö A; Soreq, Lilach; Lee, Rafael J; Pham, Stephanie T; Najafi, Allison R; Spangenberg, Elizabeth E; Wood, Marcelo A; West, Brian L; Green, Kim N

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

Csf1R抑制剂可减轻实验性自身免疫性脑脊髓炎并促进康复

Nissen, Jillian C; Thompson, Kaitlyn K; West, Brian L; Tsirka, Stella E

Microglial repopulation resolves inflammation and promotes brain recovery after injury

小胶质细胞再生可消除炎症并促进脑损伤后的恢复。

Rice, Rachel A; Pham, Jason; Lee, Rafael J; Najafi, Allison R; West, Brian L; Green, Kim N